Top Nattokinase Brands: Discover the Elite Choices!

Nattokinase, a powerful enzyme derived from the Japanese food natto, has gained popularity due to its potential health benefits, particularly in supporting cardiovascular health. As the interest in natural supplements grows, the market has introduced a wide range of brands offering nattokinase products. Some brands stand out for their quality, efficacy, and consumer trust. Whether you're a long-time enthusiast or new to this enzyme, knowing the top brands ensures you're getting the most out of your supplement. Find out more about these leading nattokinase brands below.

Illustration of nattokinase

Best brands of nattokinase in 2025

Doctor's Best

Doctor's Best is a renowned brand for producing high-quality nattokinase supplements, leveraging science-based nutrition to support circulatory health. Their nattokinase formula, derived from the traditional Japanese fermented soy food natto, contains 2,000 fibrinolytic units (FUs) per capsule and is free from Vitamin K2, making it a safe choice for those concerned about blood thinning. Since its first availability in 2007, Doctor's Best Nattokinase has been a top choice, with a non-GMO and vegan formulation. The supplement helps maintain normal fibrinogen levels in the blood, which is crucial for cardiovascular health. It is available in various package quantities, including 90 and 270 veggie capsules.

NOW Foods

NOW Foods is a renowned brand in the health supplement industry, particularly noted for its high-quality nattokinase products. Each serving of NOW Foods Nattokinase provides 2000 FU (Fibrinolytic Units), helping to maintain healthy blood clotting factors. The product is derived from natto, a traditional Japanese fermented soy food, and has been supported by both clinical and non-clinical studies for its heart health and circulation benefits. With a forecasted global nattokinase market growth rate of 2.9% CAGR from 2023 to 2033, NOW Foods is well-positioned to meet increasing demand. The recommended safe dosage of 100 to 200 mg per day, equivalent to 2,000 to 5,000 FU, aligns with NOW Foods' product specifications.

Jarrow Formulas

Jarrow Formulas is renowned for its high-quality nattokinase products, which are made through a precise fermentation process using Bacillus subtilis subsp. natto. Their nattokinase supplements, such as the Red Yeast Rice + Nattokinase, provide 2000 Fibrinolytic Units of activity per serving, supporting healthy circulation and cardiovascular health. The company ensures purity and potency by adhering to Current Good Manufacturing Practices (cGMP) and evaluating the strength and composition of all ingredients. Jarrow Formulas' commitment to scientific research and funding studies enhances the efficacy of their products. Their formulations are carefully crafted to promote optimal health, making them a trusted brand in the supplement industry.

Nutricology

Nutricology is renowned as one of the best producers of nattokinase, particularly with their NattoZyme(r) Nattokinase NSK-SD(r), which was the first nattokinase introduced into the US market and has established high standards for quality and safety. This product is derived from non-GMO soybeans and is recognized by the Japan Health and Nutrition Food Authorization (JHFA) and the Japan Nattokinase Association (JNKA) for its authenticity. NSK-SD(r) holds two Japanese and three U.S. patents, ensuring its potency and efficacy. It supports healthy blood coagulation and enhances fibrinolytic activity, with each serving containing 2000 fibrinolytic units (FU). The supplement is vegetarian, non-irradiated, and free of vitamin K2.

Life Extension

Life Extension is a renowned brand for producing high-quality nattokinase supplements, with over 40 years of dedication to delivering science-backed formulations. Their nattokinase products are designed to support healthy circulation, blood flow, and clotting function, keeping optimal fibrinogen levels in mind. The brand boasts a 98% customer recommendation rate, reflecting their commitment to health and wellness. Life Extension's nattokinase supplements are carefully extracted, purified, and packaged to ensure consistent intake, and are often recommended to be taken daily for maximum benefits. Their formulations are free from other active ingredients like vitamin K, making them suitable for those with specific dietary needs.

Source Naturals

Source Naturals is a renowned brand for producing high-quality nattokinase supplements, particularly the NSK-SD(r) form, which is patented and backed by clinical studies demonstrating its efficacy in supporting healthy blood flow and fibrinolytic processes. This enzyme, derived from the traditional Japanese soy food natto, is available in various formulations, including 33 mg and 50 mg softgels, and 100 mg capsules. The recommended dosage is 1 to 3 softgels or 1 capsule three times daily on an empty stomach. Source Naturals ensures the product is free from common allergens like yeast, dairy, egg, gluten, and wheat, and it does not contain sugar, preservatives, or artificial additives. The NSK-SD(r) nattokinase has been shown to support healthy blood clotting and circulation.

Healthy Origins

Healthy Origins is a renowned brand for producing high-quality nattokinase supplements, leveraging the fibrinolytic properties of this enzyme to support circulatory health. Derived from the traditional Japanese food natto, their nattokinase supplements are extracted from boiled non-GMO soybeans fermented with Bacillus natto. With a potency of 2000 FUs per 100mg capsule, Healthy Origins' nattokinase is designed to maintain normal circulatory health as part of a diet and exercise program. The global nattokinase market, driven by increasing health awareness, is expected to grow at a CAGR of 3.1% from 2024 to 2030, and brands like Healthy Origins are at the forefront of this trend. Their products are part of a broader heart health collection, emphasizing the importance of preventive healthcare.

Thorne Research

Thorne Research is renowned for its stringent quality control and rigorous testing protocols, making it one of the best producers of nattokinase supplements. Their products are carefully formulated to ensure maximum efficacy and safety, with a focus on avoiding common allergens like soy, as evidenced by their thorough testing methods such as the Enzyme-Linked Immunosorbent Assay (ELISA). Thorne's commitment to quality is reflected in their meticulous manufacturing processes, including the separation and quarantine of allergen-containing ingredients to prevent cross-contamination. This attention to detail has earned them a trusted reputation in the dietary supplement industry. For instance, their products are often free from hidden soy proteins, ensuring safety for those with soy allergies.

Pure Encapsulations

Pure Encapsulations is renowned for producing high-quality nattokinase supplements, such as NSK-SD(tm), which is standardized to contain a minimum of 20,000 FU (fibrinolytic units) per gram. This enzyme, derived from the traditional Japanese food natto, has been studied extensively in Japan and the United States for its potential to support healthy blood flow, circulation, and blood vessel function. With over 30 years of research and development, Pure Encapsulations ensures its products meet the strictest standards for purity and potency. NSK-SD(tm) has been shown to maintain healthy fibrinolytic activity, promote healthy circulation, and support cardiovascular health. It is recommended to take 1-2 capsules 2 times daily, 12 hours apart, with or between meals. For more information, check out their nattokinase supplements.

Solaray

Solaray is a renowned brand for producing high-quality nattokinase supplements, leveraging the fibrinolytic enzyme extracted from the traditional Japanese food natto. Their products, such as Solaray Nattokinase and Solaray Nattokinase Serrapeptase, are designed to support healthy blood flow and circulation, with the nattokinase providing up to 3000 Fibrinolytic Units per serving. Recent studies have highlighted the potential of nattokinase in reducing blood vessel blockages by up to 95.4% over a period of 12 months. Solaray's enteric-coated capsules ensure the enzymes survive stomach acid and are effectively absorbed in the small intestine, making this brand trusted for its lab-verified and clinically supported formulations.