Top Knee Replacement Brands for Optimal Joint Health

Knee replacements have become increasingly common as advancements in medical technology continue to create more durable and comfortable options for those suffering from joint pain. Several brands stand out in the field of total knee replacement, offering innovative designs and proven reliability to help patients regain mobility and improve their quality of life. Companies like Zimmer Biomet, Stryker, and DePuy Synthes consistently rank among the top choices for orthopedic surgeons, each providing a range of customizable options to meet individual patient needs. Discover the leading brands and their unique contributions to knee replacement technology in the list below.

Illustration of total knee replacement

Best brands of total knee replacement in 2025

Zimmer Biomet

Zimmer Biomet is a leading manufacturer in the global knee replacement market, dominating with a significant market share. The company's Persona® The Personalized Knee System and Oxford® Partial Knee are key contributors to its prominence, with a focus on personalized fit and function. Zimmer Biomet leads the global knee reconstruction device market, thanks to its innovative products and comprehensive knee portfolios, including total, partial, and revision knee systems. For more details on their knee solutions, visit their specialty knee products page.

Stryker

Stryker is a leading medical technology company renowned for its innovative and clinically successful total knee replacement solutions. The company holds a significant market share, with its orthopedics segment contributing 43% of total company sales, and its Triathlon Tritanium Total Knee System having helped restore function and relieve pain for over 1 million patients since its launch in 2004. Stryker's knee implants are designed to work with the body to promote a natural-like circular motion, addressing a wide variety of clinical situations during complex knee surgeries. The company dominates the global knee replacement market along with other leaders like Zimmer Biomet and DePuy Synthes, collectively holding approximately 80% of the total market share. Stryker's commitment to innovation and quality has driven double-digit growth in its orthopedics segment, such as a 21.4% growth in Q1 2021 compared to Q1 2020.

DePuy Synthes

DePuy Synthes, a subsidiary of Johnson & Johnson, is one of the leading producers in the total knee replacement market, holding a significant portion of the global market share alongside Zimmer Biomet and Stryker. The company dominates approximately 80% of the total market share with these competitors. Despite experiencing a -1.5% revenue decrease from 2018 to 2019, DePuy Synthes remains committed to innovation, particularly in making technology cost-efficient and portable to accommodate the growing trend of outpatient knee replacements. The global knee replacement market, valued at $7.8 billion in 2023, is expected to grow, with DePuy Synthes playing a crucial role in this expansion. The company's focus on durable solutions for younger, more active patients is a key driver in this market.

Smith & Nephew

Smith & Nephew is a leading manufacturer in the global hip and knee implants market, holding a 10% market share in 2023. The company utilizes advanced technologies such as 3D printing to create patient-specific surgical instruments, enhancing the precision and efficiency of total knee replacement procedures. Their innovative approach includes using MRI measurements to design customized cutting blocks, which aid in better implant placement and longevity. Smith & Nephew's commitment to research and development has led to the launch of several innovative products, including the Navio Surgical System acquired through Blue Belt Holdings in 2016. This system offers robot-assisted navigation for partial knee surgeries, further solidifying the company's position in the market. For more information on their orthopaedics solutions, visit the Smith & Nephew Orthopaedics website.

Aesculap

Aesculap, part of the B. Braun group, is a leading producer of total knee replacement systems, renowned for its advanced implant designs and innovative solutions. The VEGA System(r) and COLUMBUS(r) Total Knee Systems offer surgeons intra-operative solutions with high flexion, low wear characteristics, and stability, enhancing patient outcomes. Utilizing the OrthoPilot navigation system, Aesculap has significantly reduced incorrect implant positionings, increasing the lifetime of the implants, with over 150,000 successful knee prostheses implanted over the last 15 years. The Columbus(r) knee prosthesis has shown high patient satisfaction, with 98% of patients reporting satisfaction or very high satisfaction, and an average flexion angle of 113° one year post-procedure. Aesculap's commitment to quality and innovation has made it a trusted name in the orthopedic industry.

ConforMIS

ConforMIS is a leading brand in the total knee replacement market, renowned for its personalized and patient-specific implants. The company's iTotal CR knee implant has demonstrated a cumulative revision rate of just 0.5% at four years, significantly lower than the 1.9% rate for all total knee replacement patients. A retrospective study of 540 procedures showed 98.5% implant survivorship and 89.0% patient satisfaction for ConforMIS' patient-specific iTotal CR implants. ConforMIS' innovative use of 3D-printed surgical instruments and personalized pre-surgical plans enhances surgical outcomes and patient satisfaction. The company's strong clinical evidence and positive ratings from the Orthopaedic Data Evaluation Panel (ODEP) further solidify its position as a top producer in the industry.

Exactech

Exactech is a notable producer of total knee replacement systems, known for its innovative and clinically-proven implants. The company's knee replacement system utilizes advanced technologies such as ExactechGPS and Newton Knee Procedure, enhancing surgical precision and personalization. Despite being a small cap firm, Exactech has managed to grow its revenues, with its knee division forecasted to reach $111 million by 2026, although it currently holds just over 1% of the knee market share. The global knee replacement market, in which Exactech operates, was valued at USD 9.4 billion in 2023 and is expected to grow at a CAGR of 5.1% from 2024 to 2032. Exactech's products are designed to improve surgical experiences and patient outcomes, making it a significant player in the orthopedic device market. For more details on their offerings, visit the Exactech total knee replacement surgery page.

DJO Global

DJO Global is a leading provider of medical technologies, particularly renowned for its innovative total knee replacement solutions. The company's EMPOWR 3D Knee technology has shown significant clinical benefits, reducing patient dissatisfaction by 50% and making patients feel their knee is normal 25% more often compared to competitive implants. This dual-pivot design more closely replicates the natural motion of a healthy knee, resulting in patients being over twice as active post-surgery. Introduced in 2018, this technology has been praised for its functional accuracy and improvement in patient outcomes. With nearly 700,000 total knee replacement procedures performed annually in the U.S., DJO Global's products are crucial in addressing musculoskeletal health.

MicroPort Orthopedics

MicroPort Orthopedics is a leading multinational producer of orthopedic products, particularly renowned for its innovative total knee replacement solutions. The company's Evolution® Medial-Pivot Total Knee Replacement system has demonstrated exceptional implant survivorship of 98.8% and patient satisfaction of 95% over 17 years, with over 600,000 cases globally in the past 21 years. This system is designed to recreate natural motion and maintain better stability than traditional knee replacements, resulting in higher patient satisfaction compared to other designs. Established in January 2014, MicroPort Orthopedics has grown to become the sixth largest producer in the industry, with an estimated annual revenue of $162.4 million and a workforce of 647 employees. Learn more about their knee replacement solutions.

Medacta

Medacta is a leading producer of total knee replacement solutions, achieving significant growth with a 17% increase in sales to $551 million in 2023, outpacing the orthopedic market. Nearly 40% of these sales came from their knee replacement business, driven by personalized kinematic alignment solutions like the GMK SpheriKA, which has shown strong results in improving patient outcomes. In the first half of 2023, knee offerings grew by 27.7% to Euro 98.5 million, and by 23.2% to Euro 198.3 million for the full year, highlighting the company's robust product lineup. Medacta's innovative platforms, including the NextAR Augmented Reality Surgical Platform, enhance surgery accuracy and efficiency. The company's commitment to R&D and collaboration with surgeons globally further solidifies its position in the market. For more information about their knee replacement solutions, visit the Medacta website.