Top Tryptophan Supplement Brands for Optimal Relaxation & Mood Boost

Tryptophan supplements have gained popularity due to their potential benefits in supporting mood and sleep. Many brands have engineered high-quality products to meet these wellness needs, featuring formulations that prioritize bioavailability and purity. From industry leaders known for their rigorous testing to emerging brands focusing on sustainable sourcing, there is a diverse range of options catering to different consumer preferences. Interested in discovering which brands stand out in the crowded market of tryptophan supplements? Read on to explore our curated list of top choices.

Illustration of tryptophan supplement

Best brands of tryptophan supplement in 2025

NOW Foods

NOW Foods is a reputable brand in the natural products industry, known for its high-quality L-Tryptophan supplements. Their L-Tryptophan 500 mg Veg Capsules are free of Peak E and microbial contamination, ensuring safety and purity. Each serving contains 1 gram (1,000 mg) of free-form L-Tryptophan, which is essential for promoting healthy sleep, positive mood, and emotional well-being. The product is vegan and vegetarian-friendly, non-GMO, and manufactured in a GMP facility. With a long history of providing reliable supplements, NOW Foods has maintained its commitment to health and wellness since its inception.

Doctor's Best

Doctor's Best is a highly regarded brand for tryptophan supplements, known for its science-based nutrition and commitment to quality. Their L-Tryptophan formula, available in 500 mg veggie capsules, supports mood and sleep quality by serving as a precursor to serotonin. This product is gluten-free, non-GMO, soy-free, and vegan, catering to a wide range of dietary needs. With a 4.7 out of 5-star rating from customer reviews, Doctor's Best L-Tryptophan is a trusted choice for those seeking to enhance their overall well-being. The suggested adult use is one capsule daily, taken separately from protein-containing foods for optimum absorption.

Life Extension

Life Extension is renowned for its high-quality tryptophan supplements, such as Optimized Tryptophan Plus, which provides 1,000 mg of L-tryptophan per serving to support healthy mood, sleep, and stress response. This formula is augmented with nutrients like lysine, niacinamide, and extracts of hops and rosemary to enhance tryptophan benefits. The product undergoes rigorous manufacturing processes to ensure quality and purity. Life Extension's research and innovations have consistently demonstrated the efficacy of their supplements, including significant improvements in mood and sleep patterns in clinical trials. For instance, a trial involving 100 mg of tryptophan with vitamins B3 and B6 showed a significant improvement in mood in young adults.

Source Naturals

Source Naturals is renowned as one of the best producers of L-tryptophan supplements, offering extremely pure products that are regularly tested to ensure the highest standards of quality. Their L-tryptophan supplements support relaxation, restful sleep, and positive mood by aiding in the synthesis of melatonin and serotonin. Each serving, typically 3 tablets or capsules, contains 1.5 grams of L-tryptophan, which also supports immune functions and can convert to niacin if needed. The supplements are free from yeast, dairy, egg, gluten, soy, and wheat, and contain no preservatives or artificial additives. With various packaging options, including 60, 90, and 120 capsules or tablets, Source Naturals caters to diverse consumer needs. Discover more about their L-tryptophan supplements and their benefits.

Pure Encapsulations

Pure Encapsulations is a renowned brand for producing high-quality L-tryptophan supplements, known for their role in promoting relaxation, mood balance, and restful sleep. Their L-tryptophan supplements contain 500-1000mg of L-tryptophan per serving, often combined with vitamin B6 from pyridoxal-5-phosphate to enhance metabolism. These supplements are vegan, vegetarian, gluten-free, and lactose-free, making them accessible to a wide range of dietary needs. The recommended dosage is typically 1-2 capsules daily, taken between meals. Pure Encapsulations ensures their products are free from synthetic additives and are hypoallergenic.

Thorne Research

Thorne Research is renowned for its high-quality 5-Hydroxytryptophan (5-HTP) supplements, which are designed to enhance serotonin production, improving sleep, mood, and stress management. Each serving of Thorne's 5-HTP contains 100 mg of 5-HTP and 6.8 mg of vitamin B6 as pyridoxal 5'-phosphate, ensuring optimal conversion into serotonin. The supplement is well-absorbed, with up to 70% efficiency, and is free from common allergens like gluten, soy, and dairy. Thorne's formula is scientifically backed and recommended by healthcare practitioners, making it a trusted choice for those seeking to boost their serotonin levels. With 90 capsules per container, Thorne's 5-HTP offers a convenient and effective solution for maintaining mental well-being.

Jarrow Formulas

Jarrow Formulas is a renowned brand in the dietary supplement industry, particularly noted for its high-quality L-tryptophan supplements. Founded with a commitment to health and wellness, Jarrow Formulas has been trusted by consumers for over 50 years. Their L-tryptophan supplements are carefully crafted to support relaxation, restful sleep, and positive mood by converting to serotonin and melatonin in the body. The products are manufactured under strict Good Manufacturing Practice (cGMP) standards, ensuring purity and potency. With a 60-capsule supply providing 500 mg of L-tryptophan per serving, Jarrow Formulas offers a reliable and scientifically-backed supplement.

Solgar

Solgar is a renowned brand in the supplement industry, particularly noted for its high-quality 5-HTP (5-hydroxytryptophan) products. Since 1947, Solgar has been a pioneer in nutrition and supplements, adhering to a "Gold Standard" for excellence. Their 5-HTP complex, derived from Griffonia simplicifolia seed extract, is designed to support serotonin production, aiding in mood, sleep, and appetite regulation. Solgar's commitment to using naturally sourced ingredients and innovative manufacturing processes, such as crafting vitamins in small batches, ensures consistency and purity. The brand also celebrates over 70 years of using 100% recyclable amber glass bottles and 20 years of being carbon neutral.

Nature's Way

Nature's Way is renowned as one of the top producers of tryptophan supplements, known for its high-quality and pure L-tryptophan products. With a commitment to using only the finest ingredients, Nature's Way ensures that its supplements meet stringent quality standards, making them a trusted choice for those seeking to support mood, sleep, and overall health. The company's tryptophan supplements are often free from common allergens and fillers, enhancing their bioavailability and effectiveness. Since its inception, Nature's Way has maintained a strong reputation in the health supplement industry, with many of its products receiving high ratings from consumers. For instance, their L-tryptophan supplements are available in various dosages, such as 500mg or 1000mg per capsule, catering to different individual needs. You can explore their range of L-tryptophan supplements on their website.

Nutricost

Nutricost is renowned as one of the best producers of L-Tryptophan supplements, offering high-quality, non-GMO, and gluten-free products manufactured in GMP-compliant and FDA-registered facilities. Each capsule contains 500 mg of L-Tryptophan and 5 mg of BioPerine, ensuring maximum bioavailability. Nutricost's commitment to quality is further reinforced by third-party testing, ensuring the purity and efficacy of their supplements. With a 60-day money-back guarantee, customers can trust in the excellence of Nutricost products. Whether you are a fitness enthusiast or a wellness newcomer, Nutricost provides the necessary support for your health journey.