Top Tryptophan Brands to Boost Your Mood and Sleep Naturally

Tryptophan supplements have become a popular choice for those seeking to improve their mood and sleep quality naturally. With numerous brands available in the market, it can be challenging to determine which ones offer the best quality and effectiveness. In this article, we will explore some of the most reputable and highly recommended brands known for their high-grade tryptophan supplements. From evaluating their manufacturing standards to checking user reviews, we have compiled a comprehensive guide to help you make an informed decision. Continue reading below to discover the top brands that might suit your needs.

Illustration of tryptophan

Best brands of tryptophan in 2025

NOW Foods

NOW Foods is a reputable brand known for producing high-quality supplements, including L-Tryptophan, which is an essential amino acid crucial for mood, sleep, and appetite regulation. While the brand itself does not produce food items high in tryptophan, their L-Tryptophan supplements can help meet dietary needs. The average person requires about 280-350 milligrams of tryptophan per day, and supplements can be particularly useful for those with deficient diets. NOW Foods has been a trusted name in the health and wellness industry for decades, offering products that are often certified and compliant with strict quality standards. However, for food sources of tryptophan, one should look to animal proteins, legumes, and certain grains.

Doctor's Best

Doctor's Best is a renowned brand for producing high-quality L-tryptophan supplements, ensuring science-based nutrition and strict adherence to purity standards set by the Japanese Pharmacopeia (JP) and the United States Pharmacopeia (USP). Their L-tryptophan formula supports mood and sleep quality by serving as a precursor to serotonin and other key brain messengers. Since 1990, Doctor's Best has been dedicated to providing effective nutritional supplements, making them a trusted choice for those seeking to enhance their overall well-being. The product is non-GMO, gluten-free, soy-free, and vegan, catering to a wide range of dietary needs. Each serving contains 500 mg of L-tryptophan, available in 90 veggie capsules per container.

Nature's Way

Nature's Way, a renowned brand with over 50 years of experience, is a trusted producer of high-quality supplements, including those related to tryptophan. Although they are more famously known for their 5-HTP products, which are precursors to serotonin and indirectly related to tryptophan, their commitment to quality and natural ingredients makes them a reliable choice. Nature's Way products are manufactured in the USA from internationally sourced ingredients, ensuring strict quality control. Their supplements are free from common allergens like sugar, gluten, and artificial colors, making them suitable for a wide range of consumers. With a strong focus on delivering health through natural means, Nature's Way continues to be a leading provider in the herbal and supplement industry.

Solgar

Solgar is renowned as one of the best producers of 5-HTP supplements, offering high-quality products that support serotonin production, mood, sleep, and appetite. Their 5-HTP complex includes 100 mg of L-5-Hydroxytryptophan from Griffonia simplicifolia seed extract, along with valerian, vitamin B6, and magnesium, all packaged in 100% recyclable amber glass bottles, a practice they have maintained for over 70 years. Solgar's products are non-GMO, gluten-free, and suitable for vegans, ensuring purity and consistency. With a legacy of innovation since 1947, Solgar has been a pioneer in the nutrition and supplement industry. Their commitment to carbon neutrality and small-batch production further enhances their reputation.

Jarrow Formulas

Jarrow Formulas is renowned for its high-quality L-tryptophan supplements, which are manufactured at GMP facilities and derived from the fermentation of vegetable materials. This essential amino acid is crucial for converting into serotonin and melatonin, supporting balanced mood and restful sleep. Jarrow Formulas has a strong reputation, having been selected as the #1 Probiotics Brand for customer satisfaction in 2019 by ConsumerLab.com, with the highest percentage of Very Satisfied responses from 10,931 subscribers. Their products are backed by superior science and rigorous testing, ensuring purity and potency. With over 50 years of trust from customers, Jarrow Formulas continues to innovate and provide science-based health solutions.

Thorne Research

Thorne Research is renowned for its high-quality nutritional supplements, including those involving tryptophan and its metabolites. The company ensures the purity and potency of its ingredients through a strict control system, with every batch undergoing four rounds of testing to meet stringent standards, including compliance with current Good Manufacturing Practices (cGMP) and certifications from regulatory bodies like the NSF and Australia's Therapeutic Goods Administration (TGA). Thorne's 5-Hydroxytryptophan (5-HTP) supplement, derived from the seeds of the African plant Griffonia simplicifolia, is well-absorbed and effective in increasing central nervous system synthesis of serotonin, with about 70 percent of the supplement ending up in the bloodstream. The company's commitment to quality is further highlighted by its state-of-the-art manufacturing campus in Summerville, South Carolina, and over 65,000 hours dedicated annually to employee training. Thorne's products are trusted by athletes from over 100 professional and U.S. National teams. For more detailed information, visit their official website.

Source Naturals

Source Naturals is a renowned brand for producing high-quality L-tryptophan supplements, ensuring the highest standards of purity through regular testing. Their L-tryptophan products support relaxation, restful sleep, and a positive outlook by aiding in the synthesis of melatonin and serotonin, with each serving often including vitamin B-6 to facilitate this conversion. The supplements are free from common allergens like yeast, dairy, egg, gluten, soy, and wheat, and contain no preservatives or artificial additives. Available in various forms such as tablets, capsules, and powder, Source Naturals offers flexible dosing options, including a 1000 mg tablet option with 2352% of the daily value of vitamin B-6 per serving. This commitment to quality and purity has made Source Naturals a trusted name in the health supplement industry.

Life Extension

Life Extension is renowned as one of the best producers of tryptophan supplements, particularly with their Optimized Tryptophan Plus product, which provides 1000 mg of high-quality L-tryptophan per serving to support healthy sleep, mood, and stress response. This formula is enriched with additional nutrients like niacinamide, L-lysine, and extracts of hops and rosemary to enhance tryptophan activity. The manufacturing process is rigorous to ensure purity and safety, making it a trusted choice for those seeking to maintain optimal tryptophan levels. The product is non-GMO, gluten-free, and vegetarian, catering to a wide range of dietary needs. With its focus on promoting healthy serotonin levels, Life Extension's Optimized Tryptophan Plus is a top choice for those looking to support their mental and physical well-being.

Natrol

Natrol is renowned as one of the best producers of tryptophan supplements, particularly through their 5-HTP (5-Hydroxytryptophan) products, which support a balanced mood by aiding the body's production of serotonin. Their 5-HTP Mood & Stress Capsules, for instance, contain 50mg of 5-HTP per serving, derived from the seeds of Griffonia simplicifolia. Natrol is the #1 5-HTP brand in America, offering 100% drug-free, non-GMO, and preservative-free supplements. These products are designed to promote general well-being and are available in various formulations, including capsules and tablets that combine 5-HTP with other ingredients like L-Theanine for enhanced relaxation benefits. With a focus on clean ingredients and no artificial flavors or sweeteners, Natrol ensures high-quality supplements.

Pure Encapsulations

Pure Encapsulations is a renowned brand for producing high-quality L-tryptophan supplements, combining this essential amino acid with vitamin B6 for enhanced serotonin synthesis and emotional well-being. Their L-tryptophan products are vegan, gluten-free, and lactose-free, ensuring they cater to various dietary needs. Each capsule contains 500 mg of L-tryptophan and 3.35 mg of vitamin B6, optimized for maximum metabolic benefits. The brand's commitment to purity and quality is evident in their formulation, which is free from synthetic additives and common allergens. Pure Encapsulations has been a trusted name in the nutritional supplement industry, providing products that are backed by verifiable science.