Top Probiotic Brands for SIBO Relief

SIBO, or small intestinal bacterial overgrowth, requires careful management, and choosing the right probiotics can play a crucial role in its treatment. When considering probiotics for SIBO, it's essential to look for brands known for their quality, specific strains, and efficacy in targeting gut flora balance. Some of the top recommended probiotic brands for SIBO include Klaire Labs, which offers products with beneficial strains and are free from common allergens, and Visbiome, known for its potent formula specifically aimed at digestive health. To explore a comprehensive list of the best probiotic brands suitable for tackling SIBO, continue reading below.

Illustration of probiotic for sibo

Best brands of probiotic for sibo in 2025

Align

Align, a renowned brand, is highly regarded for its probiotic supplement, particularly the Bifidobacterium infantis 35624 strain, which has been shown to alleviate symptoms of Small Intestinal Bacterial Overgrowth (SIBO) and Irritable Bowel Syndrome (IBS). Studies have demonstrated that over 60% of patients reported significant relief from IBS symptoms after just 4 weeks of using Align, with 20% more patients experiencing adequate relief compared to placebo. The probiotic does not cause SIBO but may transiently affect lactulose breath test results without increasing symptoms. Align's probiotic has a proven safety profile and is effective in reducing abdominal discomfort, bloating, and other digestive issues.

VSL#3

VSL#3 is a highly regarded probiotic formulation, particularly effective for conditions like Irritable Bowel Syndrome (IBS) and Slow Transit Constipation (STC). Studies have shown that VSL#3 significantly increases the mean number of spontaneous complete bowel motions (SCBM) per week, with a notable increase of 1.5 SCBM/week in the STC group. It also improves quality of life scores and reduces symptom severity, as evidenced by significant improvements in IBS symptom severity scores (IBS-SSS) and quality of life scores (PAC-SYM). In patients with constipation, 70% reported relief in bowel movement frequency after a 2-week treatment with VSL#3. However, it is important to note that VSL#3 is specifically indicated for IBS and Ulcerative Colitis, and its use for other conditions like SIBO or gastroparesis may not be as well-documented. For more detailed information, visit the official VSL#3 website.

Culturelle

Culturelle is highly regarded as one of the best producers of probiotics for managing Small Intestinal Bacterial Overgrowth (SIBO) due to its clinically studied and proven strain, Lactobacillus rhamnosus GG (LGG). This strain has been shown to support gastrointestinal health effectively. While specific studies on Culturelle for SIBO are limited, the general efficacy of LGG in gut health is well-documented. Culturelle ensures the survivability and potency of its probiotics through innovative packaging that protects against light, oxygen, and moisture. With a strong reputation and high user satisfaction, Culturelle stands out as a trusted brand. For more detailed information, visit their official website.

Garden of Life

Garden of Life is a highly regarded brand for probiotics, particularly for those dealing with Small Intestinal Bacterial Overgrowth (SIBO). Their Raw Probiotics line is notable for its whole food formula, which includes Bulgarian yogurt and Wild European kefir, and features clinically studied probiotic strains that promote digestive and immune health. These probiotics are non-GMO verified, shelf-stable, and do not require refrigeration, ensuring potency through their expiration date. With diverse strains and high CFU counts, Garden of Life's probiotics are designed to support flora diversity as found in nature. Their products are cultivated and packaged in temperature-controlled facilities to maintain their effectiveness.

Metagenics

Metagenics is a leading brand in the production of probiotics for managing Small Intestinal Bacterial Overgrowth (SIBO), backed by significant clinical evidence of its effectiveness. A meta-analysis published in the Journal of Clinical Gastroenterology found that probiotics, such as those from Metagenics, achieved a SIBO decontamination rate of 62.8%, with 53.5% for probiotics alone and 85.5% when combined with antibiotics. Additionally, products like Candibactin-AR^® and Candibactin-BR^® from Metagenics have been shown to be as effective as the antibiotic rifaximin in treating SIBO when used daily over four weeks. These findings highlight the therapeutic potential of Metagenics' probiotics in restoring gut health and alleviating SIBO symptoms. The use of these probiotics also avoids the adverse effects associated with antibiotic treatments. For more information, visit their evidence on managing SIBO with probiotics.

Renew Life

Renew Life is a highly regarded brand for probiotics, particularly for managing Small Intestinal Bacterial Overgrowth (SIBO), with products like the Ultimate Care Digestive Probiotic containing 100 billion live cultures from 12 different strains. This formulation helps restore digestive balance and support a healthy flora, which is crucial for individuals with SIBO. Renew Life has been at the forefront of the digestive health movement since 1997 and has received numerous awards, including "Best of Supplements" from Better Nutrition magazine multiple times since 2011. Their products are free from artificial ingredients and preservatives, ensuring high quality and potency guaranteed through the expiration date. The brand's commitment to quality and natural ingredients makes it a trusted choice for those seeking probiotic solutions. You can explore their products on CVS's website.

Hyperbiotics

Hyperbiotics stands out as a leading brand in producing high-quality probiotics for treating Small Intestinal Bacterial Overgrowth (SIBO), with products like PRO-15 that contain 15 broad-spectrum strains, including *Lactobacillus*, *Bifidobacterium*, and *Streptococcus*, and deliver 5 billion Colony Forming Units (CFU) per BIO-tract(r) pearl. Their formulations are designed to survive stomach acids, ensuring maximum efficacy. Hyperbiotics' commitment to rigorous testing and using scientifically researched strains makes their products highly effective. For instance, studies on similar probiotic strains have shown SIBO decontamination rates comparable to antibiotics, with some achieving up to 53.2% success rates. Hyperbiotics' products are also known for their purity and lack of unnecessary additives.

Klaire Labs

Klaire Labs is recognized as one of the top producers of probiotics for SIBO treatment, offering formulations that are carefully tailored to address the specific needs of patients with Small Intestinal Bacterial Overgrowth. For instance, their products often include strains like Lactobacillus plantarum 299v, which has been shown to improve symptoms in over 78% of patients with IBS and SIBO. These probiotics are designed to enhance gut motility, reduce bacterial overgrowth, and alleviate symptoms such as bloating, abdominal pain, and diarrhea. In clinical studies, these strains have demonstrated significant efficacy, with some probiotics reducing SIBO decontamination rates by up to 62.8% and improving symptom scores significantly. The precision and effectiveness of Klaire Labs' probiotics make them a valuable component in SIBO treatment protocols.

MegaFood

MegaFood is a reputable brand for probiotics, particularly for those suffering from Small Intestinal Bacterial Overgrowth (SIBO). Their products, such as MegaFlora Probiotic Plus, contain a proprietary blend of 14 unique strains of probiotics with 50 billion active bacteria, which can support digestive and immune health. Studies have shown that probiotics can achieve a SIBO decontamination rate of 53.2%, comparable to antibiotics, highlighting their efficacy. MegaFood's probiotics, like the Digestive Probiotic Ultra Strength, include clinically tested strains such as Lactobacillus plantarum (LP-115) and Bifidobacterium lactis (HN019), which have been shown to improve bowel frequency and reduce symptoms of bloating and constipation. These formulations are also certified non-GMO, gluten-free, and made without common food allergens, making them a reliable choice for SIBO management.

Bio-K+

Bio-K+ is a renowned brand for producing high-quality probiotics, particularly effective in treating Small Intestine Bacterial Overgrowth (SIBO) and other gastrointestinal conditions. Studies have shown that 82% of patients who received Bio-K+ probiotics reported improvements, outperforming antibiotics which had a 52% improvement rate. The Bio-K+ IBS Pro, containing strains like Lactobacillus acidophilus CL1285®, Lactobacillus casei LBC80R®, and Lactobacillus rhamnosus CLR2®, has been clinically proven to normalize stool consistency and frequency, and reduce abdominal pain in IBS-D patients. These probiotics are lactose-free, vegan, gluten-free, and non-GMO, with each enteric-coated capsule containing a minimum of 50 billion colony-forming units (CFU). Bio-K+ products are certified by trusted health organizations, such as the Canadian Digestive Health Foundation, ensuring their efficacy and quality.