Top Magnesium L-Threonate Brands for Enhanced Cognitive Support

Magnesium L-Threonate has gained significant attention in the health supplement industry for its potential cognitive benefits. As consumers become more interested in the best sources of this supplement, numerous brands have stepped up to offer high-quality options. From reputable companies that have long been associated with excellence in the supplement market to newer brands bringing innovative approaches, the selection is vast and varied. Below, we've compiled a list of some of the leading brands that experts and users alike commend for their Magnesium L-Threonate products.

Illustration of magnesium l threonate

Best brands of magnesium l threonate in 2025

Life Extension

Life Extension is a renowned brand for producing high-quality magnesium L-threonate supplements, particularly their Neuro-Mag(r) formula, which has been shown to significantly improve cognitive and executive function in just 12 weeks in a randomized placebo-controlled trial involving 44 adults aged 50-70. This supplement supports healthy memory, promotes quick thinking, and enhances overall cognitive health by increasing the density of synapses in the brain. Magnesium L-threonate, developed at MIT, uniquely crosses the blood-brain barrier, making it highly effective for brain health. With a daily dose of three capsules providing 2000 mg of magnesium L-threonate, it is a favorite among customers for memory and cognitive support. Life Extension's rigorous research and manufacturing process ensures transparency and quality, backed by a 100% Satisfaction Guarantee. For more detailed information on their Neuro-Mag(r) supplement, you can visit the Life Extension product page.

Double Wood Supplements

Double Wood Supplements is renowned for producing high-quality Magnesium L-Threonate, a bioavailable form of magnesium that efficiently crosses the blood-brain barrier to support memory, overall cognitive function, and healthy sleep. Each 2000 mg dose of Magnesium L-Threonate from Double Wood Supplements contains 144 mg of elemental magnesium, which is approximately 34.29% of the daily value. Manufactured in the USA, these supplements are tested for purity and potency, and are free from soy, gluten, and GMOs. Research has shown that Magnesium L-Threonate can improve synaptic plasticity, enhance cognitive performance, and offer neuroprotective benefits. Recommended dosages range from 1000 to 2000 mg per day, with a maximum limit of 8 capsules (4 grams) daily.

Dr. Mercola

Dr. Mercola's Magnesium L-Threonate is highly regarded for its superior absorption and numerous health benefits, including support for brain, bone, and nerve health. This supplement, containing 2,000 mg of patented Magtein(r) Magnesium L-Threonate, can cross the blood-brain barrier and penetrate cell membranes, making it more effective than other forms of magnesium. It is estimated that up to 80% of Americans may have a magnesium deficiency, and Dr. Mercola's formula, introduced since 2001, is designed to address this issue without causing gastrointestinal discomfort. The supplement is free from GMOs, magnesium stearate, and other unwanted ingredients. Adults are recommended to take three capsules daily for optimal results. For more details, explore Dr. Mercola's Magnesium L-Threonate.

Jarrow Formulas

Jarrow Formulas is a leading brand in producing high-quality magnesium L-threonate supplements, particularly through their MagMind product line. MagMind features Magtein(r), a form of magnesium that has been clinically shown to cross the blood-brain barrier, supporting brain health, function, and memory in healthy adults, providing 144 mg of elemental magnesium per serving, which is 34% of the daily value. This formulation is backed by promising research and is available in various versions, including stress resistance and productivity support. The products are gluten-free, vegan, and non-GMO, ensuring they cater to a wide range of dietary needs. Jarrow Formulas maintains superior science and quality ingredients, adhering to Current Good Manufacturing Practices (cGMP).

Nootropics Depot

Nootropics Depot is renowned for its high-quality Magtein Magnesium L-Threonate, a unique form of magnesium discovered by MIT scientists, including a Nobel laureate. This supplement has shown significant benefits in improving sleep quality, enhancing memory, cognitive function, and supporting mood, with effects noticeable within 2-3 weeks. It effectively crosses the blood-brain barrier, increasing brain magnesium levels and enhancing synaptic density and plasticity. The product is sourced from the original patent holders and undergoes rigorous third-party testing to ensure purity and potency. Benefits have been observed in both animal models and human trials, with typical dosages ranging from 1.5-2 grams per day.

NOW Foods

NOW Foods is a renowned brand and one of the best producers of Magnesium L-Threonate, specifically through their Magtein product, which supports memory and learning, promotes brain health, and maintains neuronal synapse stability. Magtein, a patented form of magnesium, readily crosses the blood-brain barrier, providing 144 mg of elemental magnesium per serving, which is 34% of the daily value. This product is non-GMO, vegetarian, vegan, and kosher, and has been available since 2014. It is manufactured in a GMP facility and is free from major allergens. The suggested use is 3 capsules daily in divided doses.

Source Naturals

Source Naturals is renowned as one of the best producers of magnesium L-threonate, specifically through their Magtein™ product, which has been shown in preclinical studies to support healthy memory and learning, as well as healthy brain synapse density. This form of magnesium is theorized to provide more magnesium to the brain than other forms, with each serving containing 144 mg of magnesium, which is approximately 36% of the daily value. Introduced in 2013, Magtein™ has garnered positive reviews for its cognitive benefits. The suggested use is 3 capsules daily, preferably in divided doses, and the product is free from common allergens like yeast, dairy, egg, gluten, soy, and wheat. With a high customer satisfaction rate, Magtein™ stands out for its efficacy in supporting brain health.

Pure Encapsulations

Pure Encapsulations is renowned for its high-quality magnesium-L-threonate supplements, particularly through its product CogniMag, which combines magnesium-L-threonate with a PhytoMemory polyphenol blend to support cognitive function, learning ability, and working memory. This formulation is unique because magnesium-L-threonate is the only form of magnesium that readily crosses the blood-brain barrier, promoting optimal brain magnesium levels. Clinical trials have shown that magnesium L-threonate (Magtein™) significantly supports cognitive ability, processing speed, and executive function in participants aged 50-70 after just 6 weeks. The PhytoMemory blend, featuring extracts from wild blueberry, strawberry, and spinach, maintains healthy prolyl endopeptidase (PEP) activity crucial for learning and memory. Each serving provides 72 mg of magnesium, which is approximately 18% of the Daily Value.

Thorne Research

Thorne Research is a highly regarded brand for magnesium supplements, particularly for its Magnesium L-Threonate product, which is known for its ability to cross the blood-brain barrier and support brain health, learning, and memory function. This unique form of magnesium, often referred to as Magtein, provides 200 milligrams per serving and is third-party tested for purity and quality. Thorne's products are free of major allergens, including gluten, dairy, and soy, and are certified by NSF for Sport, making them a reliable choice for athletes. The brand's commitment to transparency includes in-house testing and the ability to check batch results online. With a reputation built over decades, Thorne's Magnesium L-Threonate is a trusted option for those seeking cognitive health benefits.

Seeking Health

Seeking Health is not specifically highlighted as a producer of magnesium L-threonate, but it is renowned for offering a variety of highly bioavailable magnesium supplements. Their products, such as Optimal Magnesium, combine forms like magnesium malate and lysinate-glycinate for optimal bioavailability, supporting GI comfort, relaxation, and natural energy production. These supplements are gluten-free, contain no fillers, and are highly rated by customers. However, for magnesium L-threonate, brands like Life Extension and Metagenics are more prominently mentioned for their cognitive health benefits and ability to cross the blood-brain barrier. Seeking Health's focus is more on general magnesium health benefits rather than specific cognitive support.