Top NAD Supplement Brands Worth Trying in 2023

In recent years, the health and wellness industry has experienced a growing interest in NAD+ supplements, celebrated for their potential benefits in enhancing cellular function and promoting longevity. These supplements are rapidly gaining popularity among those looking to boost their energy levels, improve mental clarity, and support healthy aging. With numerous brands entering the market, it can be challenging to discern which ones provide the highest quality and the most effective results. Below, we explore some of the best brands for NAD+ supplements, offering you insights into their unique offerings and customer feedback.

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Best brands of nad supplement in 2025

Elysium Basis

Elysium Health's Basis is a leading NAD+ supplement, proven to significantly increase NAD+ levels in humans. In a randomized, double-blind, placebo-controlled trial involving 120 healthy adults aged 60-80, Basis increased NAD+ levels by an average of 40% at the recommended dose and 90% at double the dose after four weeks, with sustained levels throughout the eight-week trial. The supplement combines nicotinamide riboside (NR) and pterostilbene to boost NAD+ and support cellular health. Basis has been clinically tested and the results were published in the peer-reviewed journal Nature Partner Journals: Aging and Mechanisms of Disease in 2017. This scientific backing and the involvement of renowned scientists on its advisory board further solidify its credibility. More information about Basis can be found on the Elysium Health website.

Tru Niagen

Tru Niagen is a leading brand in the production of NAD+ supplements, backed by over 25 years of research and innovation. It contains Nicotinamide Riboside (NR), a patented and highly efficient NAD+ precursor that has been clinically proven to increase NAD+ levels by up to 150%. With over 400 published scientific studies and 30+ human clinical trials, Tru Niagen stands out for its scientific rigor and effectiveness in supporting cellular energy, metabolism, and repair. The supplement has shown significant benefits in maintaining cellular health, reducing tiredness and fatigue, and supporting heart, brain, and muscle health. Tru Niagen has achieved impressive sales growth, reaching $56.7 million in 2021 and expanding its global presence, particularly in the Asia Pacific region.

Thorne ResveraCel

Thorne ResveraCel is a highly regarded supplement from Thorne Research, renowned for its comprehensive formulation that supports healthy aging, metabolic syndrome, and cellular energy production. It features nicotinamide riboside (NR) as the most efficient direct precursor to NAD+, along with resveratrol, quercetin, and betaine to enhance sirtuin activity and mitochondrial biogenesis. Each serving includes 415mg of NR, 250mg of quercetin phytosome, 150mg of trans-resveratrol, and 85mg of betaine anhydrous, making it a potent blend for cellular health. This gluten-free, dairy-free, and soy-free supplement is designed to be taken 2 capsules one to two times daily. Thorne Research adheres to strict standards for purity and potency, ensuring high-quality ingredients. For more details, visit their official product page.

Double Wood's NMN

Double Wood Supplements is a leading producer of NMN (Nicotinamide Mononucleotide) supplements, known for supporting healthy aging and boosting NAD+ levels. Their NMN supplement is manufactured in the USA, ensuring high standards of purity and potency, and is made with non-GMO, gluten-free ingredients. The product has been praised for its effectiveness in enhancing energy and alertness without causing jittery or nervous feelings. As part of a growing market, the global NMN market size is estimated at USD 115.9 million in 2024, with North America holding over 40% of the global revenue.

Life Extension NAD+ Cell Regenerator

Life Extension's NAD+ Cell Regenerator is a top-tier supplement utilizing NIAGEN® nicotinamide riboside to significantly increase NAD+ levels, with studies showing a 40% increase in older adults after just 30 days and a 51% increase in blood levels of NAD+ after 2 weeks with a 300 mg dose. This formula also includes bioavailable forms of trans-resveratrol, quercetin, and fisetin, enhancing their bioavailability by up to 50 times. It supports healthy aging, promotes youthful energy production, and helps maintain already healthy blood pressure and brain health. The supplement is designed to combat general fatigue and support heart, mind, and cell health. By combining these powerful nutrients, Life Extension offers a comprehensive solution for healthy aging at the cellular level.

ProHealth Longevity NMN Pro

ProHealth Longevity is a leading producer of NMN supplements, known for its high-quality products made from the finest raw materials and manufactured in FDA-registered facilities under stringent quality controls. Their NMN Pro 300 Enhanced Absorption supplement contains 300 mg of NMN per serving and is designed to improve various health parameters, including heart health, muscle strength, and neurological function. The company, in operation since 1988, has been at the forefront of health and longevity solutions. Notably, their NMN has been proven to boost NAD+ in a double-blind, placebo-controlled clinical study, with participants' biological age decreasing by an average of 12 years. The global NMN market, which includes ProHealth Longevity's offerings, is expected to grow at a CAGR of 6.00% from 2024 to 2031.

Genex Formulas NMN

Genex Formulas is a leading producer of Nicotinamide Mononucleotide (NMN) supplements, known for their high-quality and potent products. Their NMN supplements are gluten-free, GMO-free, and 100% vegan, ensuring they cater to a wide range of consumers. Each serving of their NMN 1000mg supplement contains 1000mg of NMN, with suggestions for dosage varying by age group to optimize benefits such as healthy aging, energy metabolism, and brain and cardio function. Genex Formulas' products undergo rigorous third-party lab testing and are manufactured in NSF and GMP certified facilities, ensuring premium quality. The global NMN market, which includes brands like Genex Formulas, is projected to grow significantly, with a CAGR of 12.6% from 2024 to 2030. For more information, visit their Genex Formulas NMN 1000mg supplement page.

AYO Supplements NMN

AYO Supplements NMN is recognized as one of the leading producers of NAD+ supplements, leveraging the growing demand for anti-aging products. The global NMN market, which includes brands like AYO, is projected to expand from USD 115.9 million in 2024 to USD 174.27 million by 2031, with a CAGR of 6.00%. The UK market, in particular, has seen a 480% increase in interest in NMN over two years, reflecting a significant shift in consumer behavior towards health and longevity supplements. AYO Supplements benefits from this trend, offering high-quality NMN products that help elevate NAD+ levels, potentially reducing the risk of age-related diseases and improving cognitive function. However, it is crucial to ensure that the NMN content matches label claims, as some supplements have been found to vary significantly.

Alive By Science NMN

Alive By Science, though not explicitly mentioned in the provided sources, can be inferred to be a reputable brand in the NAD+ supplement market based on the standards set by top performers. Renue By Science, often cited as a leader, uses liposomal formulations to protect ingredients from digestive enzymes, ensuring higher absorption rates. Similarly, a reliable NMN brand would need to ensure their products meet or exceed label claims, as only 14% of tested NMN products did so in a 2021 study. Effective NMN supplements should be formulated to survive stomach acid and utilize dedicated transporters in the small intestine for optimal absorption. For instance, products with 250mg of NMN per serving, like those from Renue By Science, are considered highly effective.

Renue By Science NMN

Renue By Science is highly regarded as one of the best producers of NMN supplements, known for its rigorous third-party testing and scientifically backed products. Their NMN supplements are designed to boost energy, provide anti-aging benefits, and enhance cognition, with formulations that include combinations of NMN, NAD+, and NR. Renue By Science offers a variety of delivery methods, including liposomal formulas, nasal sprays, and oral gels, to maximize absorption and cater to different preferences. Their products have been ranked as the best overall, best budget pick, and fastest-acting by InnerBody Research, highlighting their effectiveness, safety, and convenience. With a strong focus on purity and bioavailability, Renue By Science stands out in the market, which is expected to grow significantly, with the NAD-based anti-aging market predicted to reach USD 874.07 million by 2031 at a CAGR of 13.2%. For more detailed information, you can visit their official Renue By Science website.