Top Mushroom Supplement Brands for Optimal Wellness

Mushroom supplements have gained significant popularity in recent years due to their potential health benefits, ranging from immune support to cognitive enhancement. With a surge of brands entering the market, discerning which products are truly reliable can be challenging. Fortunately, a few standout brands have consistently demonstrated commitment to quality through rigorous testing and sustainable sourcing practices. For those eager to boost their wellness routine with the power of mushrooms, we invite you to explore the top brands we've curated below.

Illustration of mushroom supplement

Best brands of mushroom supplement in 2025

Host Defense

Host Defense Mushrooms, founded by renowned mycologist Paul Stamets, is the #1 best-selling mushroom supplement brand in the U.S., known for its USDA organic, non-GMO, vegan, and gluten-free products. Based near the Olympic Rainforest in Washington state, the company specializes in mushroom mycelium-based supplements to support natural immunity and whole body wellness. Host Defense products are scientifically validated to ensure quality and efficacy, and the company is a leader in the global medicinal mushroom market, which is projected to grow at a CAGR of 8.2% from 2024 to 2031. The brand offers a range of products, including Lion's Mane, Turkey Tail, Reishi, and multi-mushroom blends, catering to various health benefits. With a strong commitment to research and sustainability, Host Defense continues to dominate the North American market, holding 30.2% of the market share in 2024.

Real Mushrooms

Real Mushrooms has been recognized as one of the best producers of mushroom supplements, earning the "Best Mushroom Supplement Company" award from ConsumerLab for three consecutive years. This distinction is based on high consumer satisfaction ratings from over 10,000 respondents and rigorous lab tests that highlighted the superior beta-glucan content in their products, such as a beta-glucan concentration 30 times that of alpha-glucan in their lion's mane extract. Their reishi supplement also stood out with 264.5 mg of beta-glucans per serving, combined with a reasonable cost per dose. Real Mushrooms' commitment to transparency, product purity, and high standards has set them apart in the industry. The global functional mushroom market, in which Real Mushrooms operates, is projected to grow significantly, from $26.7 billion in 2021 to $65.8 billion by 2030. More information about their award-winning supplements can be found on their official website.

Four Sigmatic

Four Sigmatic is a leading brand in the functional mushroom supplements market, known for its high-quality, organic, and rigorously tested products. The brand has seen significant growth, with around 80% of its sales coming from online platforms such as its website, Amazon, and Thrive Market. In 2023, Four Sigmatic expanded its product line with the introduction of Organic Mushroom Complex Capsules and new Think Organic Coffee products, available in major retailers like Whole Foods Market and Target. The brand's products, such as its mushroom coffee, have been praised for their health benefits, including enhanced cognitive function, immune support, and stress management. Four Sigmatic's commitment to providing effective doses and transparent labeling has set it apart in the industry.

Nature's Way

Nature's Way, a renowned brand in the health supplement industry, is esteemed for its high-quality mushroom supplements, capitalizing on the growing preference for natural health solutions. In the North American functional mushroom supplements market, which was valued at USD 541.77 million in 2023 and is expected to grow at a CAGR of 15.0% from 2024 to 2030, brands like Nature's Way are pivotal due to their commitment to quality and potency. The U.S., where Nature's Way operates, dominates this market with around 88% share, driven by strong consumer demand for wellness products and robust research and development capabilities. Nature's Way's products, such as those featuring reishi mushrooms, are popular for their potential health benefits, including immune support, cognitive enhancement, and stress management. The brand's emphasis on sustainable sourcing and advanced extraction techniques further enhances its market standing.

Om Mushroom Superfood

Om Mushroom Superfood is a leading producer of certified organic, Non-GMO mushroom-based powders, known for their high micronutrient content and easy absorption. With an estimated annual revenue of $7.3 million and a growth in employee count by 13% last year, the company stands out in the health industry. Their products, such as the Mushroom Master Blend, include a range of species like Reishi, Cordyceps, and Chaga, which are valued for their immune-boosting and antioxidant properties. These powders are formulated to benefit athletic performance, recovery, and general health, and are produced in their advanced facility in Carlsbad, California. The company's innovative line of whole-food organic powders has made it a significant player in the mushroom supplement market. For more information, visit their official product page.

NOW Foods

NOW Foods is a leading producer of mushroom supplements, known for its high-quality and research-backed products. The functional mushroom supplement market, which includes brands like NOW Foods, is projected to grow at a CAGR of 15.0% from 2024 to 2030, reaching USD 1.41 billion by 2030. In 2023, the North America functional mushroom supplements market size was USD 542.15 million, with specialty stores expected to grow at a CAGR of 15.5% from 2024 to 2033. Consumers, particularly younger generations like Gen Z, are driving the market growth, with 37% consuming food and beverages boosted with mushrooms and 27% taking mushroom supplements. NOW Foods' commitment to quality and potency aligns with consumer preferences for natural and organic supplements.

Life Extension

Life Extension is a renowned brand in the health and wellness industry, particularly noted for its high-quality mushroom supplements. Their products, such as those combining reishi, shiitake, maitake, and chaga mushrooms, offer powerful immune support and have been associated with a 16% lower risk of overall mortality and a 35% reduction in all-cause mortality when consumed daily in place of processed or red meats. The brand's supplements are enriched with L-ergothioneine, an amino acid found abundantly in mushrooms, which has been linked to reduced risk of chronic diseases and improved cognitive function. With over 40 years of research and a commitment to science-backed formulations, Life Extension has earned a high customer satisfaction rate, with 98% of customers recommending their products. Their supplements are designed to promote longevity and overall health, making them a trusted choice for those seeking to enhance their well-being.

FreshCap Mushrooms

FreshCap Mushrooms is a leading brand in the mushroom supplement market, known for its high-quality capsules and powdered extracts of beneficial fungi such as Lion's Mane, Cordyceps, Reishi, Chaga, and Turkey Tail. The brand has seen significant growth, with a subscriber base of over 41,000 and a 21.72% increase in average order value (AOV) in just one month through optimized email marketing campaigns. FreshCap Mushrooms targets health-conscious adults, offering products that seamlessly integrate into daily routines. Their email marketing strategies have also led to a 10.82% increase in automation click rates and a 12.96% decrease in unsubscribe rates. This brand is part of a broader medicinal mushroom market expected to reach USD 59.41 billion by 2031, growing at a CAGR of 8.2% from 2024 to 2031.

Garden of Life

Garden of Life is a renowned brand in the mushroom supplement market, known for its high-quality, clinically studied ingredients and targeted formulas. Their Herbal Supplement for Brain Health features 500mg of organic Lion's Mane Mushroom extract, supporting memory, focus, and mood. This product is Certified USDA Organic, Non-GMO Project Verified, and NSF Certified Gluten Free, ensuring the highest quality and traceability. Garden of Life's commitment to natural health solutions aligns with the growing consumer preference for alternative medicine, as seen in the 16% year-over-year increase in vitamin supplement sales in the U.S. in 2020. The brand's emphasis on organic and vegan ingredients appeals to a wide range of consumers seeking natural wellness products.

Gaia Herbs

Gaia Herbs is a leading brand in the mushroom supplement market, known for its high-quality, organic products. In 2022, Gaia Herbs launched a new line of six mushroom capsule supplements, including Reishi, to support whole-body health and wellness. These supplements are made from 100% organic mushroom fruiting bodies and are free from pesticides, chemical fertilizers, and genetically modified seeds. The brand's commitment to quality and innovation has contributed to the strong growth of the reishi mushroom market, expected to reach $6.39 billion by 2028 with a CAGR of 8.3%. Gaia Herbs' products are designed to enhance various bodily functions, including liver health, energy, and immune support.