Top Muscle-Building Supplement Brands You Need to Know

The world of muscle-building supplements is vast and offers something for every fitness enthusiast. Whether you're a seasoned bodybuilder or just starting your journey, the right supplement brand can make a significant difference in achieving your fitness goals. Some brands have garnered a reputation for quality and efficacy, thanks to their commitment to science-backed formulas and ingredient transparency. If you're looking to enhance your workout regimen and support your muscle-building ambitions, explore the top brands that excel in this sphere below.

Illustration of muscle building supplements

Best brands of muscle building supplements in 2025

Optimum Nutrition

Optimum Nutrition is renowned as one of the best producers of muscle building supplements, particularly with its flagship products like Serious Mass and Gold Standard Whey Protein. Serious Mass provides an impressive 1,250 calories, 50 grams of protein, and 524 grams of carbohydrates per serving, making it a top choice for bodybuilders and athletes aiming to bulk up. The brand's commitment to quality is evident from its low levels of heavy metals, as highlighted in a 2010 Consumer Reports study. Optimum Nutrition's products are trusted by elite strength athletes worldwide and are part of a global protein supplements market projected to grow at a CAGR of 8.81% from 2024 to 2032. With a range of supplements supporting muscle growth, recovery, and overall performance, Optimum Nutrition solidifies its position as the world's #1 sports nutrition brand.

MuscleTech

MuscleTech, a leading brand in the sports nutrition industry, is renowned for its high-quality muscle building supplements. Since its inception on October 1, 1995, MuscleTech has been a pioneer, continuously researching, developing, and marketing effective sports supplements. The brand holds a significant presence in the global bodybuilding supplements market, which was estimated at USD 25,142.5 million in 2024, with North America holding over 40% of the global revenue. MuscleTech's partnership with SportLife Distribution enhances its market reach, allowing it to connect with thousands of supplement stores and gyms across the United States. The brand's products, such as Nitro-Tech and Cell-Tech, are popular among serious fitness enthusiasts, contributing to its reputation as a science-focused supplement company.

BSN

BSN (Bio-Engineered Supplements and Nutrition), founded in 2001, has established itself as a global leader in the sports nutrition marketplace, renowned for its dynamic, cutting-edge, and result-producing products. The company has won over 35 sports nutrition awards in the last six years, surpassing any other company in the industry. BSN's products, such as Syntha-6 and N.O. Xplode, are distributed to over 40,000 retailers nationally and in more than 90 countries worldwide. Their commitment to scientific studies and innovative partnerships has built a faithful following among athletes and fitness enthusiasts. BSN's diverse product line caters to a broad range of lifestyles and consumer types, setting it apart from competitors. For more information, visit their official website.

Dymatize Nutrition

Dymatize Nutrition is a leading brand in the production of high-quality muscle building supplements, particularly renowned for its ISO100 Hydrolyzed protein powder. This product offers 25 grams of whey protein isolate per serving, along with 5.6-5.8 grams of BCAAs, including 2.6-2.7 grams of L-Leucine, and is free from sugar and fat with less than 116 kcal per serving. Dymatize's products are formulated based on the latest scientific research and are tested in university studies and by elite athletes. The brand generates significant revenue, with estimates between $25M to $50M as of November 2024. Dymatize's supplements are popular globally, with India, Peru, and Costa Rica being among the top importers.

JYM Supplement Science

JYM Supplement Science, founded by Dr. Jim Stoppani in 2013, has established itself as a leading brand in the muscle building supplement industry. Known for its transparent and fully dosed formulas, JYM Supplement Science offers a range of products, including Pro JYM, Pre JYM, and Mass JYM, which are popular among athletes for their high-quality protein blends and effective performance enhancement. The brand has been a best-seller on Bodybuilding.com since its inception and continues to innovate with metabolic testing and research-driven formulas. Find more details about Pro JYM protein blends.

Cellucor

Cellucor is a renowned brand in the muscle building and fitness supplement industry, known for its high-quality pre-workout supplements that enhance energy, strength, and performance. The company, which holds a significant share of the North American market along with Optimum Nutrition, boasts a 35% market share in this region. Cellucor's products, such as the C4 Pre-Workout line, are designed to cater to various training goals, including muscle building and fat loss, with ingredients like beta-alanine, creatine nitrate, and caffeine. The brand is accredited by the Better Business Bureau with an A+ grade, reflecting its reliability and customer trust. With a wide range of flavors and formulations, Cellucor's supplements are popular among both beginners and advanced athletes.

Universal Nutrition

Universal Nutrition is a pioneering brand in the sports nutrition industry, renowned for its high-quality muscle building supplements. With over 40 years of experience, the company has been formulating and producing world-class products available in over 90 countries. Universal Nutrition is credited with creating the iconic Animal Pak, a revolutionary supplement that has evolved the industry. The company continues to innovate, offering a range of products including their Naturals line, catering to the growing demand for clean and natural supplements. As the sports nutrition market is expected to grow at a CAGR of 10.09% from 2021 to 2026, Universal Nutrition remains a leading force in the sector.

Evlution Nutrition

Evlution Nutrition (EVL) is a renowned brand in the sports nutrition industry, particularly noted for its high-quality muscle building supplements. Their BCAA Energy product, for instance, contains 5 grams of BCAAs per serving, along with natural caffeine, vitamins, and antioxidants to support muscle growth, energy, and focus. With a 2:1:1 BCAA ratio and 13 available flavors, EVL's supplements are popular among fitness enthusiasts. The company, founded by CEO Jeff Boyes, has an estimated annual revenue of $6.5 million and employs 30 people, highlighting its growing presence in the market. EVL's commitment to quality and customer satisfaction is evident through its 30-day money-back guarantee.

Legion Athletics

Legion Athletics stands out as a leading producer of muscle building supplements, committed to science, transparency, and honesty. Founded by Mike Matthews, the brand has served over 1 million customers and sold more than 5 million bottles since its inception. Legion Athletics is known for its clinically effective dosages and ingredients backed by peer-reviewed scientific literature, ensuring good value per serving without artificial sweeteners or unnecessary chemicals. Their supplements, such as RECHARGE and PULSE, are designed to enhance strength, muscle growth, and recovery, with noticeable results often seen within the first two weeks of use. The brand's dedication to quality and customer satisfaction has made it the #1 bestselling brand of natural sports supplements. For more information, visit Legion Athletics.

MusclePharm

MusclePharm is a renowned brand in the sports nutrition industry, particularly celebrated for its high-quality muscle building supplements. In 2022, the company announced the launch of a new line of whey protein drinks, each serving offering over 20g of protein, further solidifying its position in the market. MusclePharm's products, such as the Combat Protein Powder, deliver a commanding 25 grams of protein per serving, utilizing a blend of five unique protein sources for comprehensive amino acid infusion. Despite financial challenges, the brand has maintained a dedicated consumer base and was acquired by FitLife Brands for $18.5 million in 2023. The brand's commitment to quality is evident through its GMP-compliant manufacturing and Informed-Choice certification.