Top AHCC Supplement Brands for Immune Support

AHCC (Active Hexose Correlated Compound) is a popular supplement, particularly revered for its immune-boosting properties. This supplement, derived from medicinal mushrooms, has caught the attention of those seeking natural methods to enhance overall health and well-being. With the market flooded with options, it's essential to choose a reliable brand that ensures quality and efficacy. Below, we guide you through some of the best brands for AHCC supplements, highlighting what makes each unique in their offerings.

Illustration of ahcc supplement

Best brands of ahcc supplement in 2025

Quality of Life

Quality of Life is a leading brand for AHCC supplements, with their Kinoko Platinum AHCC containing 750mg per capsule, clinically studied in over 30 human trials, and shown to significantly improve immune response by supporting natural killer cell activity with its unique alpha-glucans, and is used by over 1,000 clinics worldwide, making it a trusted choice for immune health, with many users reporting increased energy, better medical results and overall well-being. You can find their product here on Amazon.

Source Naturals

Source Naturals, established in 1982, is recognized as a leading brand producing high-quality AHCC supplements, with their 500mg capsules designed to support immune health by potentially increasing Natural Killer cell activity, as suggested by research, while also acting as an antioxidant and supporting liver function. This supplement is made from shiitake mushroom mycelia grown in rice bran extract and is available for purchase at various retailers including Kroger.

NOW Foods

NOW Foods, established in 1968, is a reputable producer of AHCC supplements, offering both 500mg and extra-strength 750mg options derived from mushroom mycelia extract. These supplements are designed to support immune function by enhancing Natural Killer cell activity and also provide antioxidant properties, along with support for healthy liver function. They are vegetarian, soy-free, egg-free, dairy-free, nut-free, kosher, and made without gluten. NOW Foods is committed to delivering high-quality and affordable supplements to its consumers.

ImmPower

ImmPower, introduced by American BioSciences in 1999, is a leading brand of AHCC supplement, derived from a hybridized Japanese medicinal mushroom. It contains approximately 20% alpha-1,4-glucans, which are known to support immune function by enhancing Natural Killer cell activity and cytokine production. With over 80 clinical trials backing its efficacy, this product is available in vegetarian capsules, typically 500mg per capsule.

Farlong Pharmaceuticals

Farlong Nutraceutical, formerly known as Farlong Pharmaceuticals and established in 1998, is a reputable producer of the AHCC supplement, a proprietary, standardized extract of cultured Lentinula edodes mycelia, containing approximately 20% alpha-glucans. Studies indicate that this supplement can help clear persistent HPV infections with an overall response rate of 58.8% in a phase II trial, while also supporting the immune system by increasing the activity of natural killer cells and T cells. Additionally, AHCC has demonstrated the potential to reduce chemotherapy side effects and is considered safe for most individuals when taken at a dose of 1 to 3 grams a day, and is available in various forms.

Solaray

Solaray, established in 1973, is a reputable brand that produces a high-quality AHCC supplement, featuring a proprietary blend of mushroom mycelia extract at 500mg per capsule, combined with 225mg of NAC and 40mg of Beta Glucan, aiming to support the immune system with a vegetarian formula. Their product undergoes rigorous testing for purity and potency; the recommended dosage is typically one to two capsules daily, preferably between meals. The company also uses 100% PCR bottles made from plastic removed from oceans & landfills, aligning with their commitment to sustainability.

Mushroom Science

Mushroom Science, established as a leading producer of AHCC supplements, utilizes a proprietary process developed in 1987 to cultivate a specific strain of Lentinula edodes mycelia, resulting in a standardized extract rich in unique, partly acylated alpha-1,4 glucans, with over 100 published studies supporting its use since 1989, and is available through various distributors, with the bulk powder manufactured exclusively in their Japanese facilities under strict quality controls. For more information on their products, visit Aminoup's official website.

Vitacost

Vitacost, established in 1994, offers a potent AHCC supplement, with their Synergy AHCC with Vitamin C providing 1000mg of AHCC per 2-capsule serving alongside 100mg of Vitamin C, designed to promote a healthy immune response, with many users reporting positive effects on their well-being. While Vitacost is celebrating its 30th year of operation, they are offering discounts on various products including their AHCC line in 2024. You can find their product here.

Swanson

Swanson, a reputable brand with nearly 50 years of experience, offers a high-quality AHCC supplement, with each 500mg veggie capsule supporting immune health by utilizing a proprietary extract from the Basidiomycetes family of mushrooms. Research indicates AHCC can enhance the activity of natural killer cells by 200-300% and help clear HPV infections with a 58% success rate in some studies. The recommended dosage is one capsule twice daily on an empty stomach, with purity and potency testing conducted by third-party labs to ensure quality.

Life Extension

Life Extension, established in 1980, is a notable producer of AHCC supplements, offering a proprietary, standardized extract that has shown in studies a 58.8% overall response rate in clearing persistent HPV infections, with some studies using 3 grams a day. This extract, derived from cultivated mushroom mycelia including shiitake, is known for supporting a healthy immune system by enhancing the activity of natural killer and T cells, and additionally it can be used to support liver health and act as an antioxidant; Life Extension offers a 500mg AHCC supplement with a variety of purchasing options.