Tretinoin cream, a staple in skincare for its effectiveness in treating acne and reducing signs of aging, comes in various brands that have established a trusted reputation. Among the top contenders, Retin-A is often cited for its strong formulation and consistent results. Altreno offers a more cosmetic-friendly version with a lightweight, lotion-based formula, ideal for those seeking a gentler application. Differin is another popular choice, recognized for its availability over-the-counter and its efficacy in clearing up stubborn acne. To discover more about these brands and others leading the market, continue reading below.
Illustration of tretinoin cream
Best brands of tretinoin cream in 2025
Retin-A
Retin-A, a brand name for tretinoin, is one of the most effective and widely used treatments for acne and skin aging, available in various strengths such as 0.025%, 0.01%, 0.05%, and 0.1%. It is a prescription-strength topical retinoid derived from vitamin A, known for its efficacy in increasing cell turnover and reducing the appearance of fine lines and wrinkles. Retin-A has been a mainstay in dermatology, particularly in the U.S., where it is commonly prescribed for acne vulgaris, affecting over 50 million Americans annually. The product is available in cream, gel, and solution forms, with stronger concentrations showing higher effectiveness but also a greater likelihood of side effects. Retin-A is part of the broader tretinoin market, which is projected to grow significantly, with North America and Europe holding major market shares. For more information, explore the tretinoin market analysis report.
ReTrieve
Tretinoin, a potent retinoid derived from vitamin A, is widely used for its anti-aging and acne treatment properties. It is available in various strengths, such as 0.025% to 0.1%, and is prescribed for its effectiveness in increasing skin cell turnover and reducing wrinkles. The global tretinoin market is projected to grow at a CAGR of 10.1% from 2024 to 2031, reaching USD 7.5 billion by 2031. North America and Europe are the largest markets for tretinoin, driven by high prevalence of acne and increasing demand for anti-aging treatments. Tretinoin is about 20 times more potent than over-the-counter retinol and requires a prescription. For a detailed analysis, visit the tretinoin market report.
Renova
Renova, a brand of tretinoin cream, is renowned for its efficacy in mitigating fine wrinkles, mottled hyperpigmentation, and tactile roughness of facial skin. It is indicated as an adjunctive agent in comprehensive skin care and sunlight avoidance programs, with noticeable improvements seen within 3 to 6 months of therapy. Renova cream, containing 0.05% tretinoin, is formulated in a water-in-oil emulsion and has been shown to maintain improvement, primarily during the first 24 weeks of therapy. The product is part of a larger market where retinol creams and lotions, like Renova, account for a significant market share, such as 43.10% in 2023. It is crucial to use Renova as directed to avoid skin irritation and ensure optimal results. You can find more information about Renova cream on their website.
Avita
Avita is a prominent brand in the production of tretinoin cream, known for its high-quality dermatological products. Tretinoin cream by Avita, such as Avita 0.025%, is widely used for treating acne and other skin conditions, with a significant market presence driven by its efficacy. The global tretinoin market, which includes Avita products, is expected to grow substantially, with North America and Europe being the largest markets due to the high prevalence of acne. Avita's products are part of a market forecasted to increase by USD 907.11 million from 2022 to 2027, growing at a CAGR of 3.46%. The brand's reputation is bolstered by its inclusion in comprehensive market analyses highlighting the importance of prescription medications for acne treatment.
Stieva-A
Stieva-A is a renowned brand for tretinoin cream, known for its effectiveness in treating acne and promoting skin renewal. Available in various strengths such as 0.025%, 0.05%, and 0.1%, Stieva-A tretinoin cream is a prescription-only medication that has been a mainstay in dermatological treatments for decades. It is particularly praised for its ability to reduce acne lesions significantly, with studies showing a notable decrease in visible acne after 12 weeks of treatment. The cream is derived from vitamin A and is widely recommended by dermatologists for its anti-aging and skin-clearing properties. As a topical retinoid, Stieva-A tretinoin cream is available in pharmacies and through prescription dispensing, making it a trusted choice for those seeking effective skincare solutions. For information on tretinoin alternatives, consider reviewing available resources.
Refissa
Refissa, a renowned brand, is highly regarded for its high-quality tretinoin cream, particularly Refissa Tretinoin Cream, USP (Emollient) 0.05%, which is designed to mitigate fine wrinkles, mottled hyperpigmentation, and tactile roughness of facial skin. This cream, containing 0.05% tretinoin, is applied topically and has shown significant improvement in skin appearance over a period of up to six months, with most improvements noted within the first 24 weeks of therapy. Although Refissa has been discontinued by the manufacturer, it remains a benchmark for tretinoin creams, highlighting the effectiveness of tretinoin in skincare regimens. The cream's formulation includes a water-in-oil emulsion, ensuring optimal skin absorption. Refissa's product was part of a comprehensive skincare program that included sun avoidance and the use of sunscreens with at least SPF 15.
Ziana
Ziana Gel, a product from the combination of clindamycin phosphate and tretinoin, is a highly effective treatment for acne vulgaris, particularly for patients 12 years or older. It contains 1.2% clindamycin phosphate and 0.025% tretinoin, formulated as a topical gel, and is available in 30 gram and 60 gram tubes. Clinical trials involving 1853 patients showed that Ziana Gel was well-tolerated, with common adverse reactions including dry skin and nasopharyngitis, but these reactions were generally mild and decreased over the 12-week treatment period. The product is widely recommended by dermatologists for its efficacy in treating moderate to severe acne. Ziana Gel's formulation combines the antibacterial properties of clindamycin with the skin-renewing properties of tretinoin, making it a preferred choice for acne treatment. For more detailed information, you can visit the Ziana Gel comprehensive guide.
Tretin-X
Tretin-X, a brand of tretinoin cream, is highly regarded for its effectiveness in treating acne, fine wrinkles, and skin discoloration. It is available in various strengths, including 0.025%, 0.05%, and 0.1%, catering to different skin needs. Tretinoin creams like Tretin-X work by keeping skin pores clear and stimulating the production of new collagen, leading to smoother, younger-looking skin. With over 50 million Americans affected by acne each year, Tretin-X is a popular choice due to its proven efficacy, as highlighted by the American Academy of Dermatology. Studies have shown that even low to moderate strength tretinoin creams, such as 0.025% to 0.05%, can significantly reduce fine wrinkling and hyperpigmentation after 24 weeks of use. For more detailed information about tretinoin topical usage, visit the Mayo Clinic's guide on tretinoin.
Atralin
Atralin, a brand of tretinoin, is a highly regarded product for the topical treatment of acne vulgaris, containing 0.05% tretinoin by weight. It is a translucent to opaque, pale yellow gel that is part of the retinoid class of compounds, derived from vitamin A. Atralin is widely used due to its efficacy in reducing acne and skin discoloration, with each gram of the gel containing 0.5 mg of tretinoin. The product is available in 45 g tubes and is known for its specific formulation that includes various components like benzyl alcohol and glycerin to enhance its efficacy. Atralin's popularity is reflected in the growing demand for tretinoin products, particularly in North America and Europe, where it is one of the leading treatments for acne. For more detailed information about Atralin and its uses, you can visit their official site.
Acretin
Tretinoin, a derivative of vitamin A, is a highly effective treatment for acne, anti-aging, and other dermatological conditions. The global tretinoin market is projected to grow at a CAGR of 10.1% from 2024 to 2031, reaching USD 7.5 billion by 2031. North America and Europe are the largest markets for tretinoin, driven by the high prevalence of acne and the use of tretinoin in skincare routines. Tretinoin is available in various formulations, including creams, gels, lotions, and solutions, catering to different skin types and needs. It is prescribed by healthcare professionals and available through pharmacies, drugstores, and online retail platforms.
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