Top TMG Supplement Brands: Unveiling the Best in the Game

The world of Tri-Methyl Glycine (TMG) supplements has seen a growing interest as more individuals recognize its potential health benefits. Many brands have stepped up to offer high-quality TMG products, ensuring consumers have access to pure and effective options. With so many choices available, it can be challenging to identify which brands truly stand out in terms of quality and reliability. For a comprehensive guide on the best TMG brands on the market today, explore the article below.

Illustration of TMG

Best brands of TMG in 2025

Metagenics

Metagenics is a leading global producer and distributor of high-grade micronutrition products, including Trimethylglycine (TMG), with a strong presence in multiple countries such as the United States, Australia, and Europe. In 2021, Metagenics Europe reported a total turnover of more than 87 million euros, highlighting the company's financial strength and market influence. As a key player in the micronutrition sector, Metagenics leverages its global knowledge and scientific insights to maintain a leading role. The company's products, including those containing TMG, are valued for their health benefits such as liver support, heart health, and improved athletic performance. Metagenics' commitment to research and development ensures the continuous innovation and quality of their nutritional supplements. For more information about Metagenics and their global reach, visit their official website.

Life Extension

Life Extension is a renowned brand in the supplement industry, particularly notable for its high-quality TMG (Trimethylglycine) products. TMG, also known as glycine betaine, is effective in supporting cardiovascular health by reducing homocysteine levels, with studies showing it can lower homocysteine by up to 50%. Life Extension's TMG formula is designed to maintain healthy homocysteine levels and is often recommended at a starting dose of 2000 mg per day. The brand's commitment to science-backed products has made it a trusted name, with over 40 years of experience in providing clinically-studied vitamins and supplements. Life Extension's TMG products are part of their comprehensive health maintenance programs, ensuring users receive advanced nutritional support.

Jarrow Formulas

Jarrow Formulas is a renowned brand in the dietary supplement industry, particularly noted for its high-quality TMG (trimethylglycine) products. As a key player in the TMG supplement market, which is expected to grow at a CAGR of 12.1% from 2024 to 2030, Jarrow Formulas has established itself through its science-backed and customer-trusted products over the past 50 years. Their TMG crystals, for instance, provide essential methyl donors, similar to folic acid, supporting various health benefits. The global TMG supplement market, valued at $65 million in 2023, is projected to reach $144.5 million by 2030, with Jarrow Formulas being one of the leading brands in this segment. The company's commitment to quality and customer health advocacy has earned it a strong reputation.

Thorne Research

Thorne Research is a leading producer of high-quality nutritional supplements, including products like Methyl-Guard Plus, which supports normal homocysteine metabolism with vitamins B2, B6, B12, folic acid, and Betaine Anhydrous (TMG). In 2022, Thorne HealthTech reported a 27.7% year-over-year increase in net sales to $63.0 million, with direct-to-consumer sales growing by 46.1%. The company is known for its rigorous science testing and clean manufacturing processes, ensuring the highest quality ingredients. Thorne's commitment to excellence is reflected in its state-of-the-art facilities and extensive employee training, with over 65,000 hours dedicated annually. Thorne's products are certified by stringent regulatory agencies, including the U.S. FDA and Australia's Therapeutic Goods Administration (TGA).

Pure Encapsulations

Pure Encapsulations is renowned for its high-quality supplements, including Trimethylglycine (TMG), formulated with rigorous scientific backing and free from unnecessary additives and common allergens. With over 30 years of research and innovation, their products are highly bioavailable, such as the Homocysteine Factors supplement which includes 500mg of TMG per serving, along with vitamins B6, B12, and folate to support homocysteine metabolism and cardiovascular health. Their supplements are manufactured to avoid artificial additives, GMOs, and environmental contaminants, ensuring purity and potency. Pure Encapsulations is the #1 most recommended professional supplement brand by healthcare professionals. Their products are sourced from trusted suppliers and undergo stringent testing.

NOW Foods

NOW Foods is a renowned brand and a leading producer of TMG (Trimethylglycine) supplements, known for its high-quality and effective products. Their TMG 1000 mg tablets, available in a 100-tablet package, support healthy homocysteine levels, facilitate methylation processes, and aid in liver detoxification and DNA repair. Produced in a GMP-certified facility, these supplements are vegetarian, vegan, and kosher, ensuring they meet stringent quality standards. With a history dating back to 1968, NOW Foods has established itself as a trusted name in the dietary supplement industry. The suggested use is 1-3 tablets twice daily, preferably with food.

Doctor's Best

Doctor's Best is highly regarded for its high-quality TMG (Trimethylglycine) supplements, which are often recommended for their purity and effectiveness. Their TMG products are typically manufactured to GMP standards and are third-party tested to ensure 99% purity, which is crucial for supporting methylation processes and complementing NAD+ boosters like NMN. Users often appreciate the lack of unnecessary additives and the vegan-friendly formulation. For optimal results, a daily dose of 500-1000 mg of TMG is commonly suggested, aligning with recommendations from longevity researchers like Dr. David Sinclair. This dosage helps maintain healthy methylation levels without compromising other bodily processes.

Source Naturals

Source Naturals is a renowned brand in the health supplement industry, particularly noted for its high-quality Trimethylglycine (TMG) products. As a leading manufacturer, Source Naturals ensures that their TMG supplements are made with authentic and potent ingredients, such as the 750mg TMG tablets that support heart health and liver function. The global TMG market, in which Source Naturals is a key player, is expected to grow significantly, with North America holding around 40% of the global revenue due to increasing consumer awareness about TMG's health benefits. Source Naturals' commitment to quality and research aligns with the market's growth trajectory, which is projected to expand at a CAGR of 12.1% from 2024 to 2030. Their products are designed to support overall health and wellness, making them a trusted choice among consumers.

Designs for Health

Designs for Health is a trusted brand in the health supplement industry, particularly renowned for its evidence-based TMG products. Since 1989, the company has been developing research-driven formulations that support optimal health and wellness. Their TMG supplements are designed to enhance methylation processes, which is crucial for biochemical reactions and overall health. The brand's commitment to using high-quality, synergistic formulations has made it a favorite among healthcare professionals globally. For instance, their B-Supreme product, which includes TMG and choline, is highly regarded for its effectiveness in optimizing B vitamin efficacy. More information about their offerings can be found on their official website.

Kirkman Labs

Kirkman Labs is renowned for producing high-quality Trimethylglycine (TMG) supplements, derived from beets, which are hypoallergenic and free from common allergens such as milk, eggs, fish, and gluten. Their TMG products support the methylation pathway, enhance heart health, boost athletic performance, and promote healthy insulin levels. TMG from Kirkman Labs is a more active methyl donor than DMG, converting homocysteine to methionine and supporting cardiovascular and liver health. Some of the methionine from TMG is converted into SAMe, which helps maintain healthy serotonin levels, supporting mood, energy, and concentration. Kirkman's Ultra Tested® process ensures the purity and efficacy of their products.