For parents concerned about their baby’s diaper rash, selecting the right cream can be crucial in ensuring comfort and healing. Many brands stand out for their effectiveness and gentleness, making them popular choices among caregivers. Factors such as ingredients, consistency, and pediatrician recommendations often guide decision-making as parents seek the best option for their little ones. If you're eager to see which brands top the list and why they are trusted by parents worldwide, read on to discover more below.
Illustration of diaper rash cream
Best brands of diaper rash cream in 2025
Aquaphor
Aquaphor is a leading brand in the diaper rash cream market, renowned for its effective and soothing products. It boasts the highest sales in the category, with 190,482 units sold and a revenue of $2,478,355.33 in January 2024, capturing an 18.94% market share in sales. The Aquaphor Baby Diaper Rash Cream is formulated with zinc oxide and panthenol, creating a protective barrier against irritants and moisture, and is praised for being preservative and fragrance-free. This product is highly recommended by parents and has been a trusted name for generations.
Desitin
Desitin is a leading brand in the diaper rash cream market, renowned for its effective and hypoallergenic products. The Desitin Maximum Strength Zinc Oxide Diaper Rash Paste, introduced in December 2021, contains 40% zinc oxide and provides relief from diaper rash in just one use, with 90% of babies showing noticeable relief within 12 hours. Desitin Daily Defense Cream, formerly known as Rapid Relief, is another popular product that forms a protective layer on the skin, providing overnight relief and reducing redness and irritation significantly. These products are pediatrician-tested and dermatologist-approved, ensuring safety and efficacy for sensitive skin. Desitin's commitment to quality and innovation has made it the #1 pediatrician and parent recommended diaper rash brand.
Bepanthen
Bepanthen is a leading brand in the diaper rash cream market, known for its high-quality and effective products. It holds a significant market share, with approximately 17.79% of the global baby diaper rash cream market as of recent reports. Bepanthen Nappy Rash Ointment is particularly praised for its breathable barrier properties and the inclusion of Pro Vitamin B5, which aids in natural skin recovery and protection. The product is free from fragrance, preservatives, and colorants, making it suitable for even the most delicate skin. Its effectiveness has been clinically proven, reducing the incidence of nappy rash when used at every nappy change.
Butt Paste
Boudreaux's Butt Paste is a highly trusted brand for diaper rash cream, developed by pharmacist George Boudreaux in the 1970s. Known for its maximum strength formula containing 40% Zinc Oxide, it provides overnight protection and instant soothing relief, without dyes, preservatives, parabens, and talc, making it a pediatrician-recommended choice. With over 40 years of trust from parents and pediatricians, Boudreaux's Butt Paste has gained endorsements from notable figures, driving significant demand, such as after Oprah Winfrey's recommendation. The brand has experienced several ownership changes, including acquisitions by C.B. Fleet Company, Inc. in 2011 and later by Prestige Brands in 2016. For more details on this popular product, visit the Boudreaux's Butt Paste page on Target.
A&D Ointment
A+D Original Ointment is a highly recommended and pediatrician-approved diaper rash cream, known for forming a protective barrier to seal out wetness and prevent diaper rash. It contains lanolin and petrolatum, and is free of dyes, phthalates, and parabens, making it a gentle and effective solution. The ointment also provides relief for chapped, chafed, and cracked skin, and includes vitamins A and D. With over 80 years of trust, A+D Original Ointment is a staple in baby skin care. It is widely available and has a strong presence in the market, which is expected to grow at a CAGR of 5.6% from 2023 to 2033. For more detailed information about this effective ointment, visit the A+D Original Ointment product page.
Weleda Calendula
Weleda Calendula is renowned for producing high-quality diaper rash creams, leveraging 100 years of experience in natural product formulation. Their Calendula Diaper Rash Cream contains 12% pharmaceutical-grade zinc oxide, providing effective relief and protection against minor skin irritations and diaper rash. This cream is enriched with organic calendula extract from Weleda's Biodynamic gardens in Germany and is free from synthetic preservatives, fragrances, and petroleum-derived raw materials. Certified Natural by NATRUE, it is also dermatologist-tested and safe for sensitive baby skin. The cream is formulated with fair trade beeswax and skin-friendly sweet almond and sesame seed oils, ensuring a breathable and nourishing barrier for the skin.
Mustela
Mustela is a leading brand in the diaper rash cream market, renowned for its clinically proven Diaper Rash Cream 1 2 3, which prevents, relieves, and recovers skin irritation with its 3-in-1 action. This fragrance-free cream is formulated with 9.9% Zinc Oxide and 98% plant-based ingredients, including Sunflower Oil Distillate and Avocado Perseose, making it hypoallergenic and safe for babies from birth onwards. Tested under pediatric and dermatological control, it has been confirmed by 100% of dermatologists and pediatricians to have a preventive effect. The cream is effective from the first use and continues to work between diaper changes to prevent future rash recurrences. Mustela's commitment to natural and safe ingredients has made it a trusted choice among parents.
Babyganics
Babyganics is highly regarded as one of the best producers of diaper rash cream, known for its non-toxic, non-allergenic, and non-irritating products. Their diaper rash cream contains zinc oxide and other natural ingredients like calendula extract, aloe, and beeswax, making it effective in protecting and soothing irritated skin. As highlighted in a 2015 review, Babyganics products have been praised for their safety and efficacy, with the diaper rash cream being a standout for its long-lasting protection and gentle formulation. The brand's commitment to using safe and natural ingredients has made it a favorite among health-conscious parents. Babyganics' products are free from toxins, endocrine disruptors, parabens, phthalates, and carcinogens, ensuring the best care for babies' delicate skin.
Burt's Bees Baby
Burt's Bees Baby is renowned for producing one of the best diaper rash creams, formulated with 40% zinc oxide, the maximum strength allowed without a prescription, to effectively treat and prevent diaper rash. This 100% natural origin cream is enriched with shea butter, lavender oil, and jojoba seed oil, making it gentle and soothing for baby's delicate skin. It is pediatrician-tested, clinically proven to be safe and non-irritating, and free from parabens, phthalates, petrolatum, and SLS. The cream is also not tested on animals, aligning with ethical consumer preferences. With its emollient layer that protects against moisture, it is a favorite among parents for its effectiveness and natural ingredients.
Triple Paste
Triple Paste is highly regarded as one of the best producers of diaper rash cream, praised for its high-performance treatment and prevention capabilities. Recommended by pediatricians and tested by dermatologists, it contains 12.8% non-nano zinc oxide, oat extract, glycerin, and beeswax, making it a trusted choice for over 50 years. It is free from fragrances, parabens, preservatives, phthalates, and dyes, ensuring it is safe and gentle for daily use. In a survey by The Bump, 94% of parents valued a cream that works quickly and efficiently, with Triple Paste consistently ranked as the best for this need.
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