Top Amitriptyline Brands: A Curated Choice for Quality and Effectiveness

Amitriptyline, a well-known antidepressant commonly prescribed for various conditions such as depression, anxiety, and chronic pain, is available under several reputable brand names. Among the best-known brands are Elavil, Amitrip, and Endep, which have consistently been trusted by physicians and patients alike for their effectiveness and reliability. These brands offer a range of dosages, allowing for tailored treatment plans suited to individual needs. To explore a comprehensive list of top amitriptyline brands that might suit your specific requirements, please continue reading below.

Illustration of amitriptyline

Best brands of amitriptyline in 2025

Elavil

While the brand name Elavil has been discontinued in the U.S. since 2000, it was a notable brand of amitriptyline, a tricyclic antidepressant, that was initially FDA-approved on April 7, 1961, and is still available as a generic medication; amitriptyline is used to treat depression, with typical adult dosages ranging from 50mg to 100mg daily, though it can go up to 150mg under a specialist's supervision. Common side effects include dry mouth, constipation, and drowsiness, and although it is primarily used for depression, it also has off-label uses like migraine prevention. For more detailed product information, you can visit their website.

Endep

Endep, a brand of amitriptyline hydrochloride, is available in 10mg, 25mg, and 50mg tablets, with the 50mg strength primarily for maintenance treatment of depression, while the lower doses can be used at any stage of treatment; this medication, belonging to the tricyclic antidepressant (TCA) class, works by correcting the imbalance of chemicals in the brain, particularly amines, and is also used off-label for conditions like bedwetting and nerve pain, with the original approval of amitriptyline by the FDA occurring in 1961, though the Endep brand itself has been discontinued. It's important to note that while Endep was a trade name, generic forms of amitriptyline are still widely available; this medication is prescribed for both humans and animals, particularly for dogs and cats experiencing behavioral issues, such as anxiety and excessive grooming, with common side effects including drowsiness and dry mouth, and the product was prepared in August 2022. For more information, you can visit NPS MedicineWise.

Levate

Levate, a brand of amitriptyline, is a tricyclic antidepressant used to treat mood disorders, with its effectiveness stemming from balancing neurotransmitters like serotonin and norepinephrine. While it may start showing effects within 3-4 days, full results can take up to 30 days. Although it is available in various strengths such as 10mg, 25mg, 50mg, and 75mg tablets, its use for animals is considered "off-label". The brand, produced by Biomed Pharma, has been on the market since the 1960s but currently has a dormant status. For more information on the product, you can visit the Rexall website.

Amitriptyline HCL

While several manufacturers produce generic Amitriptyline HCL, there isn't a single brand definitively considered the "best" as effectiveness is similar across generic versions. Amitriptyline HCL is a tricyclic antidepressant, first approved by the FDA in 1961 under the brand name Elavil (which has since been discontinued), and is now primarily available as a generic medication; it is used to treat depression and neuropathic pain by increasing serotonin and norepinephrine levels in the brain. In 2023, the global market size for Amitriptyline was estimated at $607 million with North America holding a 34.8% market share. Generic Amitriptyline HCL is available in various strengths, such as 10mg, 25mg, 50mg, 75mg, 100mg, and 150mg tablets, with bioequivalence studies showing similar absorption and efficacy to branded versions. For more information, you can consult your local pharmacist or healthcare provider, or visit a general resource on Amitriptyline.

Amitriptyline Hydrochloride

Amitriptyline Hydrochloride, a widely prescribed generic medication, is known for its effectiveness in treating depression, with some manufacturers reporting up to 80% patient improvement in clinical trials. The generic version was first introduced in 1961, and has become a mainstay in mental health treatment because of its affordability and efficacy. Numerous brands manufacture this tricyclic antidepressant, but specific production volume percentages are not publicly available. This generic version provides the same therapeutic benefits as its brand-name counterpart, and is often favored due to cost savings. For more information, you can visit websites like Drugs.com which provide comprehensive details about generic and brand versions of this drug.

Tryptomer

Tryptomer, a prominent brand, has been a reliable producer of amitriptyline for decades, with studies showing a high efficacy rate of over 80% in treating certain types of depression since its introduction in 1961; its formulations are recognized for consistent quality and bioavailability, ensuring patients receive the intended therapeutic effect; they have maintained a strong position in the pharmaceutical market due to their commitment to rigorous manufacturing standards, solidifying their position as a trusted source for this essential medication; with continued research and development, Tryptomer’s commitment to excellence is evident in every batch produced, making them a leading choice for healthcare professionals. For more information, visit their medicine profile.

Saroten

Saroten, a brand of amitriptyline, has been marketed in several European countries since its initial approval in 1961, with its tablets containing a range of strengths like 10, 25, 50, and 75 mg of amitriptyline base. A study showed that Saroten tablets contain around 96% of the declared amount of amitriptyline base, demonstrating its quality. This medication is used to treat conditions such as depression and chronic pain and is available in multiple forms including tablets, modified-release capsules, and solutions for injection. It is produced by companies like Bayer GmbH and Lundbeck A/S. For more details, visit the European Medicines Agency website.

Triptafen

Triptafen, a brand known for amitriptyline, is available as tablets containing either 25mg or 10mg of amitriptyline hydrochloride combined with 2mg of perphenazine, and while amitriptyline is also sold under other names like Elavil, Triptafen has been a recognized name since at least 1974. Triptafen is a tricyclic antidepressant and has been a leading medication in this category for over 40 years, though it is important to note that side effects may occur more frequently when compared to other antidepressants. For more information, visit the Multiple Sclerosis Trust's page on amitriptyline and Triptafen.

Laroxyl

Laroxyl, a brand known for its amitriptyline, has been a trusted option with a 25mg tablet available since the 1960s, often prescribed for depression with effectiveness rates reported around 60-70% in clinical studies, while also being used for nerve pain management and migraine prevention; its formulation allows for flexible dosing under medical supervision, making it a versatile treatment choice. For more detailed product information, visit the product information page.

Lentizol

Lentizol, a brand of amitriptyline manufactured by Pfizer Ltd, is available in 25mg and 50mg modified-release capsules. While it has been a widely used tricyclic antidepressant for decades, studies show that patients on amitriptyline experience 13.1% more side effects compared to other antidepressants, although the dropout rate is similar with an odds ratio of 0.99. It's important to note that Lentizol, while a brand name of amitriptyline, is now discontinued for primary care in the NHS. For more detailed information about this product, visit their NHS information page.