Top-Rated Accutane Brands for Acne Treatment

Accutane, known as isotretinoin, is a powerful medication often prescribed for severe acne that hasn't responded to other treatments. With its increasing demand and effectiveness, many pharmaceutical brands have ventured into its production, providing a range of options for consumers. Among the top brands, you'll find diverse offerings that vary in formulations and price points, ensuring that there's a suitable choice for every individual need. To help you make an informed decision, we've compiled a list of some of the best brands known for their quality and reliability in sourcing Accutane. Read on to explore the recommended brands and find the one that best fits your requirements.

Illustration of accutane

Best brands of accutane in 2025

Roche

Roche, originally a pioneer in developing isotretinoin, marketed under the brand name Accutane, achieved a remarkable success rate of approximately 90-95% in treating severe acne, particularly cystic acne. Although they ceased production in the U.S. in 2009 due to business reasons despite its efficacy, Roche's legacy continues as other companies produce generic versions. The effectiveness of isotretinoin remains, often with a single course leading to long-term remission for 60-70% of patients. The medication works by reducing oil production, preventing clogged pores, and increasing skin cell turnover and is generally prescribed for a 5-month course. The original product monograph, including safety information, can be found on their official website.

Teva Pharmaceuticals

Teva Pharmaceuticals is a major manufacturer of isotretinoin, the generic form of Accutane, marketing it under the brand name Claravis, with various strengths like 10mg, 20mg, 30mg, and 40mg capsules. They launched the first generic version of Absorica (isotretinoin) in the US in 2021, offering 10 mg, 20 mg, 25 mg, 30 mg, 35 mg, and 40 mg options. While the original brand, Accutane, by Roche, was discontinued in the US in 2009 due to business reasons, Teva has become a key player in providing this medication for severe acne. With over 3,500 products and a global reach to approximately 200 million people using their medicines daily, Teva demonstrates its significance in the pharmaceutical industry. Isotretinoin is a retinoid that effectively reduces sebum production and is used to treat severe recalcitrant nodular acne in patients 12 years and older. Teva's Claravis is available as a generic alternative to the original Accutane, providing a more affordable option for those who require this treatment. For more details, visit their Claravis isotretinoin capsules page.

Mylan

Mylan, a prominent pharmaceutical company, produces Amnesteem, a generic form of Accutane, which is an effective isotretinoin medication available in 10mg, 20mg, and 40mg strengths, and is considered bioequivalent to the original Accutane, which had over half a billion dollars in sales in the U.S. before it was discontinued by Roche in 2009. Mylan acquired exclusive US marketing rights for isotretinoin in 2002 and continues to produce generic versions, demonstrating their commitment to providing this crucial treatment for severe acne. Mylan also offers the product Clarus in Canada, with a similar formulation to Amnesteem. You can find more information about Mylan's products.

Amnesteem

Amnesteem, produced by Cipla USA, is a brand of isotretinoin, a medication also known as Accutane, and is considered a very effective treatment for severe nodular acne, with 75% of reviewers reporting a positive effect, though it requires strict adherence to the iPLEDGE REMS program due to its teratogenic risks; it is available in oral capsules of various dosages, and while side effects like dry skin are common, it can offer a long-term solution for those who have not responded to other treatments. You can find more information about Amnesteem.

Absorica

Absorica, a brand of isotretinoin from Sun Pharmaceutical, launched in 2012, is a highly prescribed oral treatment for severe acne, with studies showing at least a 90% reduction in nodular lesions in approximately 70% of patients, and its unique formulation allows for better absorption even when taken without food, unlike some other isotretinoin products; furthermore, Absorica LD, introduced in 2020, utilizes micronization technology to optimize absorption at a 20% lower dose and has shown low relapse rates over a 104-week post-treatment period, with 82.5% of patients not requiring retreatment.

Claravis

Claravis, manufactured by Teva Pharmaceuticals, is a well-regarded brand of isotretinoin capsules, a medication used to treat severe nodular acne. As a generic version of the previously popular Accutane, it is considered a reliable option with 74% of reviewers on Drugs.com reporting a positive experience. Available in 10 mg, 20 mg, 30 mg, and 40 mg dosages, Claravis was initially approved by the FDA in 2006. It is subject to the iPLEDGE REMS program to prevent fetal exposure, as it can cause severe birth defects. Typically taken for 4 to 5 months, Claravis should be taken with food for better absorption. For more information, visit the Claravis product page on Teva Pharmaceuticals' website.

Myorisan

Myorisan, produced by Akorn, is a brand of isotretinoin capsules available in 10mg, 20mg, 30mg, and 40mg strengths, specifically indicated for treating severe nodular acne that is unresponsive to other treatments. While it was not the original brand, this isotretinoin product, similar to others, is part of the iPLEDGE REMS program, which was implemented in 2005 to mitigate the significant risk of birth defects associated with pregnancy during medication usage. In 2015, the sales of the 10mg, 20mg, and 40mg strengths reached approximately $436 million, while the 30mg strength achieved $209 million in sales.

Zenatane

Zenatane, by Dr. Reddy's Laboratories, is a therapeutic equivalent generic version of Accutane (Isotretinoin), available in 10 mg, 20 mg, 30 mg, and 40 mg capsules, and was initially launched in the US market in 2013, with a re-launch in 2019. While the brand and generic had US sales of approximately $525 million (MAT) for the twelve months ending in March 2019, it is essential to acknowledge that Isotretinoin, including Zenatane, carries a risk of severe birth defects if taken during pregnancy, requiring strict adherence to the Risk Evaluation and Mitigation Strategy (REMS) program. Despite a recall of over 325,000 cartons in 2024 due to failed dissolution specifications, Zenatane remains a significant option for treating severe nodular acne. You can find more information about Dr. Reddy's and their products.

Sotrane

Sotrane, produced by Sandoz, is a well-regarded brand of isotretinoin, a medication with around 80-90% success rate in treating severe acne, particularly nodular acne, that has not responded to other treatments, though some may experience a temporary worsening of acne initially. It is important to note that isotretinoin, including Sotrane, can cause side effects, such as dry skin, chapped lips, and nosebleeds; and more seriously, can cause birth defects if taken during pregnancy, hence patients must adhere to strict guidelines, and the medication is available by prescription only. Sandoz, a global leader in generic medicines, aims to make high-quality medicines affordable, with their products serving millions of people worldwide, while also having patient support programs to facilitate access to complex treatments. You can find more information about Sandoz and their products.

Acnotin

Mega We Care's Acnotin, containing isotretinoin, is a well-regarded brand for treating severe nodular acne, often when other treatments have failed, with typical dosages ranging from 0.5 to 1 mg/kg daily for 15-20 weeks. It's known to reduce sebum production and inflammation, and while effective, it is important to note that about 32.7% of patients may experience relapse within 12 months of treatment. It's crucial to take it with food and under the supervision of a dermatologist. You can find more information about their products on their website: Mega We Care.