Top Papaya Enzyme Brands for Optimal Digestive Health

Papaya enzyme supplements have gained popularity for their potential digestive health benefits, made from the naturally occurring compound found in papayas known for aiding in protein breakdown. Among the myriad of options available, some brands stand out for their commitment to quality, consistency, and ingredient transparency. From chewable tablets to capsules, these brands ensure you receive the most effective dose to support your digestive system. To explore which brands top the list and why they might be the right choice for you, continue reading below.

Illustration of papaya enzyme

Best brands of papaya enzyme in 2025

American Health

American Health is renowned as one of the best producers of papaya enzyme supplements, offering a naturally-sourced digestive aid that combines freshly ripened papaya fruit with enzymes like papain, amylase, and protease. These enzymes help in the digestion of proteins and carbohydrates, promoting nutrient absorption and supporting gastrointestinal wellness. The supplements are available in various sizes, including 100, 250, and 600 tablets, and are free from common allergens like yeast, wheat, lactose, egg, and grapefruit. With a high customer satisfaction rate, as evidenced by a 4.68-star rating from 152 reviews, American Health's papaya enzyme supplements are a trusted choice for digestive health. The products are convenient, delicious, and can be taken after any meal to provide extra digestive support.

NOW Foods

NOW Foods is a renowned brand known for its high-quality papaya enzyme products, which are designed to support digestive health by breaking down proteins, carbohydrates, and fats. Their papaya enzyme lozenges are made from natural papaya extract and are available in convenient chewable forms, such as the 180-lozenge pack. These products are rigorously tested to ensure quality and efficacy, reflecting the brand's commitment to empowering healthier lives. With a wide range of supplements, NOW Foods has established itself as a trusted name in the health and wellness industry. Their products are backed by decades of experience and a strong customer base.

Nature's Plus

Nature's Plus is a renowned brand for producing high-quality papaya enzyme supplements, trusted by loyal consumers for over 50 years. Their Papaya Enzyme Chewables contain 6 mg of papain per serving, along with other digestive enzymes like amylase and protease, to support healthy digestion and ease discomfort from occasional bloating and gas. These chewable tablets are free from artificial colors, preservatives, and major allergens, making them a safe and effective choice. With a commitment to family-driven values and a history of innovation, Nature's Plus ensures its products are potent and efficacious. Their papaya enzyme supplements are available in various sizes, including 180 and 360 count options. For more information on their Papaya Enzyme Tablets, explore the available selections.

Solaray

Solaray is renowned as one of the best producers of papaya enzyme supplements, offering powerful digestive support through their expert enzymatic blends. Their products, such as the Solaray Super Papaya-Plex™ and Solaray Papaya Enzyme, contain 100% natural ingredients, including papain, amylase, protease, and bromelain, which aid in the digestion of proteins, carbohydrates, and fats. These supplements are available in convenient, delicious chewable forms, such as fresh mint and natural pineapple flavors, and are designed to promote efficient digestion and enhanced nutrient absorption. Each serving often includes a potent 2 mg of papain, supplying 100,000 FCC PU+, ensuring efficacious post-meal digestive support. With a commitment to quality and natural sourcing, Solaray's papaya enzyme supplements are a popular choice for maintaining daily digestive health.

Country Life

Country Life is renowned as one of the best producers of papaya enzyme supplements, offering high-quality products like their Papaya Digestive Support and Tropical Papaya Chewables. These supplements contain essential digestive enzymes such as papain and protease, sourced from whole papaya fruit, to help break down proteins and support gut health. Each serving of their Papaya Digestive Support provides 56,000 USP units of papain, along with other enzymes like alpha amylase and protease, to alleviate symptoms of slow or problematic digestion. Available in convenient chewable wafers, these products are designed to be taken up to three times a day after meals. With servings per container ranging from 50 to 125, Country Life ensures a reliable and consistent digestive support solution.

Source Naturals

Source Naturals is a renowned brand for producing high-quality digestive enzymes, including those with papaya enzymes, though they are more recognized for their broad-spectrum enzyme blends. Their Essential Enzymes Ultra, for example, is a Bio-Aligned Formula that includes multiple levels of enzymes to digest food across a wide range of pH levels, supporting digestive comfort. This formula contains five types of proteases and enzymes for carbohydrates, fats, fiber, and milk sugars. While they do not specifically focus on papaya enzymes, their comprehensive enzyme blends are highly regarded for their effectiveness. Source Naturals ensures their products are vegetarian, gluten-free, and devoid of artificial fillers or colors.

GNC

GNC is renowned for its high-quality papaya enzyme products, offering comprehensive digestive support with rich ingredients like probiotics, enzymes, and herbal extracts. Their papaya enzyme supplements, such as the Papaya Enzyme - 600 Tablets, provide 200 servings, making them a convenient and effective choice. GNC ensures the purity and potency of their products, aligning with consumer trust and satisfaction. With a long history of providing health and wellness products, GNC has established itself as a reliable brand since its inception. The papaya enzyme from GNC is derived from the papaya plant, leveraging the natural anti-inflammatory properties of papain.

Thompson

Thompson brand is renowned for its high-quality papaya enzyme products, particularly papain, which is extracted from the latex of the papaya plant (Carica papaya). The enzyme complex includes 73% glycyl endopeptidase/chymopapain, 22% caricain, and 5% papain, as documented by the European Food Safety Authority (EFSA). Thompson's papain is optimized for various industrial applications, including brewing, flavor production, and protein hydrolysis, with optimal activity at pH 6-8 and temperatures of 60-75°C. The company ensures stringent manufacturing processes, including multiple solid-liquid separation and concentration techniques, to maintain purity and safety standards. This attention to detail has established Thompson as a trusted name in the food enzyme industry. For more information, visit their official website.

Sundown Naturals

Sundown Naturals is renowned for its high-quality papaya enzyme products, ensuring they are free from genetically modified ingredients, gluten, dairy, and artificial flavors. Their papaya enzyme supplements are formulated to provide essential digestive support, leveraging the natural enzymatic properties of papaya. With a commitment to health and nutrition, Sundown Naturals has gained trust among consumers, particularly for its papaya enzyme chewable tablets. These products are designed to be easy to consume and effective in aiding digestion. The brand's focus on purity and effectiveness has made it a preferred choice for those seeking natural health solutions.

Spring Valley

Spring Valley is renowned for its high-quality papaya enzyme complex, formulated to support digestive health with a vegetarian-friendly, gluten-free, salt-free, and lactose-free composition. The product, available in 180-count chewable tablets, leverages the natural enzymes from papaya fruit to aid in food breakdown. Produced under strict quality guidelines, Spring Valley's papaya enzyme complex is backed by a quality guarantee, reflecting the brand's commitment to health and well-being. This dietary supplement is designed to be part of a balanced lifestyle, aligning with the brand's mission to provide affordable, nature-inspired products. With its papaya flavor and comprehensive formulation, Spring Valley's product stands out as a reliable choice for digestive health support.