Cold sores, often caused by the herpes simplex virus, can be a persistent and uncomfortable issue for many people. A common treatment approach is the use of lysine supplements, known for their potential to reduce the frequency and severity of outbreaks. With numerous brands available, it can be a daunting task to choose the right lysine supplement. In this article, we have compiled a list of the best lysine brands to help you make an informed decision. Discover which brands stand out in terms of effectiveness, quality, and value for money below.
Illustration of lysine for cold sores
Best brands of lysine for cold sores in 2025
Quantum Health Super Lysine+
Quantum Health Super Lysine+ is a leading brand in managing and preventing cold sore outbreaks, backed by clinical tests that prove its effectiveness in reducing the duration and frequency of herpes simplex virus (HSV) recurrences. This advanced formula combines six immune-boosting nutrients, including L-Lysine, vitamin C, garlic bulb, echinacea, propolis, and licorice root, to provide comprehensive support for oral health and immune system strength. Up to 80% of American adults carry the HSV virus, and Super Lysine+ has been shown to cut healing time in half and relieve pain. The product is made in the USA and is available at various natural stores and online retailers. With its award-winning formula and scientifically-backed ingredients, Quantum Health Super Lysine+ is a reliable choice for cold sore management.
L-Lysine by NOW Foods
L-Lysine by NOW Foods is a highly effective supplement for treating cold sores, with studies showing that it can reduce the frequency and duration of herpes simplex virus (HSV) outbreaks. For instance, a six-month study found that participants taking L-Lysine had 2.4 times fewer HSV outbreaks and significantly diminished symptoms compared to the placebo group. Additionally, 85% of subjects who took 1,000 mg of oral L-Lysine reported their lesions healed in five days, highlighting its efficacy. The recommended dosage for prophylaxis is 500-1,000 mg, and up to 6,000 mg during an active outbreak. This supplement is well-regarded for its safety and lack of adverse side effects.
Solgar L-Lysine
Solgar L-Lysine is a highly recommended supplement for managing cold sores, with 98% of users endorsing the brand according to a 2017 global survey. This supplement provides a potent 1000mg dose of free-form L-Lysine, which is essential for skin health and collagen production. Made from non-GMO, chemical-free ingredients, Solgar L-Lysine is suitable for vegans and free from common allergens like gluten, dairy, and sugar. It is manufactured in small batches to ensure high quality and is bottled in recyclable amber glass to protect against heat, light, and moisture. Solgar has been innovating in the supplement industry since 1947. For more information about this product, visit Solgar L-Lysine supplement.
Life Extension L-Lysine
Life Extension L-Lysine is highly regarded as one of the best producers of lysine supplements for treating cold sores, with their 620mg dose showing efficacy without sacrificing safety. Studies have shown that lysine can reduce the frequency and duration of cold sore outbreaks, with up to 87% of participants reporting cure by day 6 of treatment. This supplement is particularly effective because it interferes with the absorption of arginine, a necessary amino acid for the herpes simplex virus to replicate. Life Extension's formulation is well-tolerated, with a safe upper intake limit of around 6g per day, although typical dosages range from 1-3 grams daily for treating herpes outbreaks. By enhancing calcium absorption and promoting collagen production, Life Extension L-Lysine also supports overall health.
Nature Made L-Lysine
Nature Made L-Lysine is a highly regarded supplement for managing cold sores, given its high-quality ingredients and precise dosage. Each daily tablet provides 1000 mg of L-lysine, an essential amino acid that can help reduce the frequency and duration of cold sore outbreaks by interacting with arginine and inhibiting herpes simplex virus replication. Studies suggest that L-lysine can lead to significant improvements, with one study showing 80% of patients had their cold sores resolved within six days. This supplement is particularly beneficial for those who do not obtain enough lysine through their diet. Nature Made ensures the product is gluten-free, has no added colors or preservatives, and meets high quality standards. For more details, visit the Nature Made official website.
Doctor's Best L-Lysine
Doctor's Best L-Lysine is a highly regarded supplement for managing cold sores, leveraging the amino acid's ability to interfere with arginine absorption, which is essential for herpes simplex virus replication. Studies suggest that lysine can reduce the duration and frequency of cold sore outbreaks, with some patients reporting lesions healing in as few as five days when taking 1,000 mg of oral lysine daily. However, it is crucial to consult a doctor before using lysine, especially for pregnant or breastfeeding individuals due to limited safety data. Doctor's Best ensures high-quality, science-based nutrition, making their L-Lysine supplement a reliable choice. The recommended dosage is typically 1 gram three times daily for active outbreaks and 1 gram daily for prevention. For more information, visit their official website.
Superior Labs L-Lysine
Superior Labs L-Lysine is a highly regarded supplement for managing cold sores, given its high-quality formulation and lack of artificial additives. Studies suggest that lysine can significantly reduce the recurrence and severity of cold sore outbreaks, with up to 87% of participants reporting a cure by day 6 of treatment. Lysine works by interfering with the absorption of arginine, a necessary amino acid for the herpes simplex virus to replicate. The recommended dosage is typically 1 gram daily to help prevent cold sores and 1 gram three times daily to manage active infections. However, it is crucial to consult a doctor before starting any supplement, especially for pregnant or breastfeeding individuals. For more detailed information, visit the Superior Labs website.
Pure Encapsulations L-Lysine
Pure Encapsulations L-Lysine is a highly regarded supplement for managing cold sores, with studies showing that 85% of subjects taking 1,000 mg of oral lysine reported their lesions healing in five days, compared to those not taking lysine. This amino acid supports immune function, promotes healthy gum and lip tissue, and enhances calcium absorption. It is recommended to take 2-6 capsules per day, in divided doses, between meals. L-Lysine is produced from grain fermentation and is free from common fillers, making it a reliable choice. It has been praised for its effectiveness in preventing and reducing the severity of cold sore outbreaks. For more information, visit the Pure Encapsulations L-Lysine product page.
Source Naturals L-Lysine
Source Naturals L-Lysine is a highly regarded supplement for managing cold sores, with its formulation supporting the reduction of HSV outbreaks and their severity. Studies have shown that L-Lysine, such as that provided by Source Naturals, can help cold sores heal faster, with one study indicating that 87% of patients saw their cold sores disappear by day six of treatment. The supplement is available in various forms, including 500mg and 1000mg tablets, and is free from common allergens like yeast, dairy, and gluten. It is particularly beneficial for vegans and vegetarians due to its plant-based compatibility. Source Naturals ensures high-quality standards and purity in their products. For more details, visit their official product page.
Sports Research L-Lysine
Sports Research L-Lysine is a highly regarded brand for managing cold sores, leveraging the amino acid's ability to interfere with arginine absorption, which is crucial for herpes simplex virus (HSV) replication. Studies suggest that lysine can reduce the recurrence and severity of cold sore outbreaks, with some participants reporting a cure rate of up to 87% by day 6 of treatment. The recommended dosage for oral supplements is typically 1 gram three times daily for active outbreaks and 1 gram daily for prevention. Lysine is generally safe when taken at recommended dosages but should be avoided during pregnancy due to lack of safety data. By incorporating lysine into their regimen, individuals can potentially reduce the frequency and duration of cold sore episodes. For more information, visit the Sports Research L-Lysine product page.
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