Top Diosmin Brands: Expert-Recommended Options for Vascular Health

Diosmin is a popular supplement known for its potential benefits in improving vascular health, often used for conditions like chronic venous insufficiency and hemorrhoids. With numerous brands offering diosmin supplements, choosing the most effective and trustworthy options is crucial for consumers. Top brands are typically preferred for their quality assurance, purity of ingredients, and proven efficacy based on consumer reviews and certifications. If you're curious to explore which brands have made it to our list of the best diosmin options on the market, please see below for more detailed insights.

Illustration of diosmin

Best brands of diosmin in 2025

Venixxa

Venixxa is a leading brand in the production of diosmin, a citrus flavonoid medication, offering clinically proven and effective treatments for chronic venous disease and hemorrhoids. The active ingredient in Venixxa is a micronized purified flavonoid fraction (MPFF), containing 90% diosmin and 10% other flavonoids, ensuring up to 2x better absorption. Clinical studies have shown that Venixxa can relieve leg pain and sensations of heaviness and swelling by up to 50% after one month and up to 63% and 72% respectively after two months. For hemorrhoids, Venixxa provides rapid relief, with 42% of users experiencing symptom reduction in two days and 80% reporting stopped bleeding in three days. Venixxa is recommended by doctors as the #1 over-the-counter brand for treating mild-to-moderate chronic venous disease.

Detralex

Detralex is a leading brand in the production of diosmin, a citrus flavonoid used to support vascular health, particularly in treating venous-lymphatic insufficiency and hemorrhoidal crises. The formulation of Detralex includes a micronized fraction of flavonoids, comprising 90% diosmin and 10% other flavonoids equivalent to hesperidin, which enhances bioavailability despite the poor water solubility of these compounds. Studies have shown that Detralex achieves a maximum bioavailability of about 1.26%, significantly higher than other similar products. In clinical trials, diosmin from Detralex has demonstrated efficacy in healing venous trophic ulcers, with a complete healing rate of 61.3% compared to 47.7% in control groups. The recommended dosage varies depending on the condition, with up to 6 tablets per day for acute hemorrhoidal crises. For more information, you can visit the Store of Health.

Daflon

Daflon, manufactured by Laboratoires Servier, is a leading brand for diosmin, a micronized purified phlebotonic flavonoid fraction containing 90% diosmin and 10% hesperidin. It is widely used to treat venous insufficiency, heavy legs, pain, and hemorrhoids, with moderate certainty evidence supporting its effectiveness in reducing oedema. Daflon's pharmacological activity involves preventing perivascular edema and inhibiting inflammatory processes by antagonizing prostaglandin E2 and thromboxane biosynthesis. The recommended dosage is 2 tablets of 500mg daily for venous insufficiency and varies for acute hemorrhoidal attacks. Daflon is available in several countries, including France, Spain, Malaysia, and Belgium, but is not FDA-approved in the United States. For more detailed information, you can visit its Wikipedia page.

Diosmin Expert

Diosmin, particularly the Diosvein^tm brand by Exquim, S.A., is renowned for its high quality and safety profile, having been used for over 30 years as a vascular-protecting agent. It is recommended at a daily dosage of 500-1000 mg, with a maximum duration of use of 3 months, and is not intended for children, pregnant, or nursing women. The product complies with the specifications of the European Pharmacopoeia and has been supported by numerous clinical trials demonstrating its safety and efficacy in managing chronic venous insufficiency, hemorrhoids, and other vascular conditions. With millions of tablets sold worldwide since 1971, Diosmin has established a strong history of use and safety. The market for Diosmin is projected to grow significantly, with the global market size expected to reach USD 900 million by 2031, growing at a CAGR of 8% from 2024 to 2031. For further details, you can access the FDA documentation on Diosmin.

DiosVein

DiosVein, a brand renowned for its high-quality diosmin supplements, stands out as a leading producer in supporting vascular health. Diosmin, the key ingredient, has been clinically shown to reduce edema and mean leg circumference in patients by significant margins, with one study demonstrating a decrease in inflammatory markers such as TNF alpha, VEGF-C, VEGF-A, IL-6, and FGF2. The combination of diosmin with other flavonoids like hesperidin enhances its efficacy in maintaining circulatory system structure and function. Produced through advanced biosynthetic pathways, diosmin from DiosVein ensures a pure and environmentally friendly product, avoiding toxic byproducts associated with traditional semi-synthetic methods. With its rapid absorption and long half-life of 26 to 43 hours, DiosVein's diosmin supplements offer sustained benefits for vascular health. For more information, visit DiosVein on Swanson Vitamins.

Diosamin

Diosmin, produced by companies like HealthTech BioActives, is a highly regarded venotonic flavonoid used for the chronic treatment of conditions such as varicose veins, hemorrhoids, and heavy legs syndrome. HealthTech BioActives, one of the world's largest producers of Diosmin, offers a GMP-certified API that promotes blood circulation and vascular health, produced through a solvent-free method and complying with Ph. Eur and USP Monographs. Their production process is certified by various standards including HACCP, FAMI-QS, and ISO 14001, ensuring high quality and sustainability. The company's EcoVadis certification highlights their commitment to environmental responsibility. With a projected market growth of 8% from 2024 to 2031, Diosmin continues to be a significant player in the pharmaceutical and nutraceutical sectors. For more detailed information, visit Diosmin product page.

CircuVein

Flora's CircuVein is a leading product for vein health, clinically proven to reduce the visible signs of varicose veins and alleviate symptoms of chronic venous insufficiency and hemorrhoids. It contains 450 mg of diosmin and 50 mg of hesperidin per capsule, bioflavonoids sourced from Spanish oranges, which have been studied since 1971 and shown effective in numerous clinical trials. The formula is vegan, gluten-free, and dairy-free, making it accessible to a wide range of users. Recommended usage involves taking 1 capsule twice daily with meals for at least 2 months to see beneficial effects. CircuVein has been recognized for its safety and effectiveness in reducing swelling, heaviness, and inflammation associated with varicose veins. More detailed information about CircuVein can be found on Aviva Health's website.

Vasculera

Vasculera is a leading brand in the production of diosmin, a highly purified flavonoid fraction derived from citrus, specifically designed to manage chronic venous disease (CVD). Each Vasculera tablet contains 600 mg of diosmin glycoside and 30 mg of alka4-complex, which works synergistically to enhance venous tone, reduce inflammation, and manage lymphatic drainage. With over 20 years of global use and recommendation in clinical-practice guidelines, Vasculera has been shown to decrease edema and improve symptoms of CVD in as little as one week, with significant benefits observed in 4-8 weeks. Clinical trials have demonstrated no adverse effects on cardiovascular, hepatic, or renal function, and diosmin has been designated as "generally recognized as safe" (GRAS). The proprietary alka4-complex has seven times more pH neutralizing capacity compared to sodium bicarbonate, ensuring effective management of local metabolic acidosis.

VitaMedica

VitaMedica is a respected brand in the beauty and wellness space, offering high-quality nutraceuticals and cosmeceuticals that have been recommended by thousands of doctors for over 25 years, supporting the recovery, skin health, and overall wellness of over one million patients. Their products are guided by science and proven through clinical experience, ensuring optimal absorption and utilization by the body. Although VitaMedica is not specifically known for producing diosmin, other brands like Nutratech are more relevant, with their Diosmin Complex having been marketed in the United States and complying with European Pharmacopoeia specifications, involving a minimum daily dose of 1000 mg and a maximum of 3000 mg in safety studies. For more information about VitaMedica, visit their website.

Hemovel

Hemovel is a leading brand in the production of diosmin-based treatments, particularly for hemorrhoid relief. Clinically proven, Hemovel's 7-day treatment reduces the duration and severity of hemorrhoids, relieving symptoms such as pain, swelling, and bleeding. With its active ingredient diosmin, which has been trusted for over 20 years in Europe, Hemovel is generally well-tolerated and preferred by 85% of hemorrhoid sufferers for its convenience and mess-free administration. Available in Canada since 2014, Hemovel's oral pills are easy to use, with a simple dosage of 1 pill three times a day for 4 days, then 1 pill twice a day for 3 days. The product has received positive reviews, with many users recommending it for its effectiveness. For more information, visit Hemovel's official website.