Top Digestive Enzyme Brands for Optimal Gut Health

Digestive enzymes have gained popularity as a natural aid to improve digestion and enhance nutrient absorption. With the increasing demand, various brands have entered the market, offering a wide range of enzyme supplements designed to fulfill different dietary needs. Key factors to consider often include the source of the enzymes, additional ingredients, and specific digestive issues they aim to address. To help you navigate this extensive market, we've compiled a list of the best brands for digestive enzymes based on quality, effectiveness, and customer feedback below.

Illustration of digestive enzymes

Best brands of digestive enzymes in 2025

Garden of Life

Garden of Life is a prominent player in the digestive enzymes market, known for its whole food, plant-based enzyme formulas. The company offers a variety of products, such as Dr. Formulated Enzymes Organic Digest+ and RAW Enzymes, which cater to different digestive health needs. Garden of Life is part of a market that is expected to grow significantly, with the global digestive enzymes market projected to reach $0.73 billion by 2025 at a CAGR of 12%. The company's products are popular due to their organic and natural ingredients, aligning with consumer preferences for healthier supplements. Garden of Life, along with other major players, contributes to the market's growth driven by increasing demand for advanced digestive enzyme supplements. For more information, visit the Garden of Life enzyme product page.

Enzymedica

Enzymedica is a leading producer of digestive enzymes, renowned for its high-quality, scientifically proven products. Since 1998, the company has been committed to using the best ingredients and cutting-edge research to formulate effective enzyme-based supplements. Enzymedica's products, such as Digest Basic and Digest Gold, are industry leaders, with Digest Gold being one of the top-selling digestive enzymes in the US market according to SPINS. The company's exclusive Thera-blend technology ensures enzymes work effectively across a broader pH range, enhancing digestive health. Enzymedica is also GMP Registered through NSF International, ensuring the highest standards of quality and purity. For more information, visit Enzymedica's official website.

Doctor's Best

Doctor's Best stands out as a renowned brand in the digestive enzymes market, celebrated for its science-based nutrition and high-quality products. Their digestive enzymes are formulated to support digestive wellness by effectively breaking down carbohydrates, proteins, and fats, ensuring better nutrient absorption. The brand caters to health-conscious consumers with vegetarian and non-GMO options, making it a popular choice. Each serving size of 1 veggie capsule contains 450 mg of a robust digestive enzyme blend, designed to deliver optimal digestive support. With a focus on digestive health, the market for digestive enzymes, including brands like Doctor's Best, is projected to grow significantly, with the global market expected to reach $1.64 billion by 2031, growing at a CAGR of 8.7% from 2022 to 2031.

Now Foods

NOW Foods is a leading producer of digestive enzymes, known for its high-quality and effective supplements that cater to diverse dietary and health needs. The company's products are driven by advancements in enzyme technology, enhancing stability and effectiveness, and are part of a market projected to grow at a 9.4% CAGR from 2024 to 2032. NOW Foods operates in a highly fragmented market, adopting key strategies such as product innovation and geographical expansion to maintain its market position. Their digestive enzyme supplements are popular in regions like North America, where the market is expected to register significant growth due to increasing health consciousness and the rise in gastrointestinal disorders. With a strong focus on natural and organic ingredients, NOW Foods aligns with consumer preferences for personalized and preventive healthcare solutions. For more details, visit their official website.

American Health

American Health is a renowned brand in the digestive enzymes market, known for its high-quality products that aid in efficient digestion and nutrient absorption. The global digestive enzymes market, which includes brands like American Health, is projected to grow at a CAGR of 8.7% from 2021 to 2031, reaching a market size of $1.64 billion by 2031. American Health's products often contain essential enzymes such as amylase, lipase, and protease, which are crucial for breaking down carbohydrates, fats, and proteins. The increasing prevalence of digestive disorders and the rise in health consciousness among consumers drive the demand for such supplements. For instance, the North American market, where American Health operates, is expected to remain dominant due to the presence of major key players and significant R&D activities.

Pure Encapsulations

Pure Encapsulations is a leading brand in the production of high-quality digestive enzymes, known for their comprehensive and vegetarian-friendly formulations. Their Digestive Enzymes Ultra product supports the breakdown and absorption of proteins, carbohydrates, fats, fiber, and dairy, with a proprietary enzyme blend active across a wide pH range. This formula includes enzymes such as proteases, lipase, amylase, and lactase, among others, to promote optimal nutrient bioavailability and reduce symptoms like bloating and gas. The market for digestive enzymes is expected to grow significantly, with a compound annual growth rate (CAGR) of 12.0% projected to reach $1.73 billion by 2028, reflecting increasing consumer awareness and health-conscious trends. Pure Encapsulations' products are free from unnecessary additives and common allergens, ensuring high-quality and hypoallergenic ingredients.

Source Naturals

Source Naturals is a renowned brand in the digestive enzymes market, offering products like Essential Enzymes that break down multiple food groups, including carbohydrates, proteins, fats, and fiber, aiding in maximum nutrient absorption. This Bio-Aligned Formula is available in convenient vegetarian capsules, making it accessible for a wide range of consumers. The product contains a broad-spectrum blend of enzymes, such as fungal pancreatin, acid stable protease, and lipase, ensuring comprehensive digestive support. With its all-vegetarian and broad-spectrum formulation, Essential Enzymes caters to the growing demand for natural digestive health solutions, aligning with the increasing health consciousness among consumers. The digestive enzyme market, which includes products like Essential Enzymes, is projected to grow at a CAGR of 9.4% from 2024 to 2032, driven by advancements in enzyme technology and rising health awareness.

Integrative Therapeutics

Integrative Therapeutics is a renowned brand in the digestive enzyme market, known for its high-quality supplements that aid in proper digestion and nutrient absorption. The brand's products, such as their enzyme blends, are formulated to address various digestive issues, capitalizing on the growing demand driven by rising health consciousness and the increasing prevalence of gastrointestinal disorders, which affect over 40% of the global population. The market for digestive enzymes is expected to grow at a CAGR of 8.3% to 9.5% over the forecast period, with microbial enzymes, like those offered by Integrative Therapeutics, gaining traction due to their high stability and productivity. North America, where Integrative Therapeutics operates, dominates the market, driven by factors such as the rising cases of gastrointestinal disorders and an aging population. The brand's commitment to innovation and quality aligns with the market's growth drivers, making it a significant player in the industry. For more information about their products, visit the Integrative Therapeutics website.

MaryRuth Organics

MaryRuth Organics is renowned for its high-quality digestive enzymes, formulated to support gastrointestinal health and enhance nutrient absorption. Their products, such as the Digestive Food Enzyme Blend and Gluten Digestive Enzymes, are designed to aid in the digestion of various nutrients, including gluten, fats, and proteins. With over 12,000 five-star reviews, these supplements have proven effective in reducing bloating, gas, and discomfort. The brand ensures utmost care and quality, with products that are vegan, gluten-free, non-GMO, and made in a GMP-certified facility. MaryRuth Organics also holds Clean Label Certification on over 130 products, verifying their purity from industrial contaminants and toxins.

Thorne Research

Thorne Research is a leading producer of digestive enzymes, known for its high-quality and scientifically-backed products. The company's enzymes are formulated to address various digestive health needs, with a focus on bioavailability and efficacy. Thorne Research's products are often recommended by healthcare professionals, reflecting their trust in the brand's commitment to research and innovation. The global digestive enzyme market, which includes brands like Thorne Research, is expected to grow at a CAGR of 9.5% from 2023 to 2030, reaching $1,354.2 million by 2030. Thorne Research's microbial enzymes, in particular, are gaining traction due to their high stability and productivity. For more details, visit the Thorne Research official website.