Top Omeprazole Brands: Relieve Heartburn with These Leading Options!

Finding the right brand for omeprazole, a popular medication used to treat conditions like acid reflux, can make a significant difference in managing your symptoms effectively. Various pharmaceutical companies offer this medication, each ensuring their product meets stringent quality standards. In this article, we've compiled a list of some of the most trusted and reliable brands on the market known for their effectiveness and consumer satisfaction. To explore which brand might be the best fit for you, check out the detailed list below.

Illustration of omeprazole

Best brands of omeprazole in 2025

Prilosec

Prilosec, a brand of omeprazole developed by AstraZeneca, has been a dominant player in the proton pump inhibitor (PPI) market, capturing a significant market share. In 2000, omeprazole under the Prilosec brand was the world's bestseller, with annual US sales of $6 billion. However, with the expiration of its patent, AstraZeneca successfully transitioned to esomeprazole (Nexium), maintaining their market leadership. By 2014, esomeprazole accounted for 77% of prescriptions for the omeprazole/esomeprazole binomial, while omeprazole held 23%. Omeprazole remains widely used, especially with its availability over-the-counter, contributing to its continued market growth. For more details on their product portfolio, please visit AstraZeneca's website.

Nexium

Nexium, produced by AstraZeneca, is a leading brand in the proton pump inhibitor (PPI) market, particularly with its drug esomeprazole, which is the S-isomer of omeprazole. Launched in the US in 2001, Nexium quickly gained dominance, with sales exceeding those of its predecessor, omeprazole, by 2010, reaching US$5.63 billion in annual sales. The drug is widely used to treat conditions such as GERD, heartburn, and other disorders involving excessive stomach acids. By 2014, esomeprazole accounted for 77% of prescriptions for the omeprazole/esomeprazole binomial in Australia, while omeprazole held only 23%. The shift to over-the-counter (OTC) status in 2014 further boosted its market share and accessibility.

Zegerid

Zegerid, a product from Salix Pharmaceuticals, is a notable brand in the omeprazole market, known for its effective combination of omeprazole and sodium bicarbonate. It is indicated for the reduction of risk of upper GI bleeding in critically ill adult patients and is available in specific dosages, such as the 40 mg oral suspension. The annual U.S. sales of Zegerid capsules have been significant, approximating $195 million according to IMS Health data as of 2010. This product has contributed to the growth of the omeprazole market, which is expected to expand at a CAGR of over 6.4% from 2024 to 2036. The combination therapy in Zegerid, similar to other omeprazole products, has shown positive outcomes in clinical trials, particularly in H. pylori elimination therapy. For detailed prescribing information, you can refer to their product information guide.

Omeprazole OTC

Kirkland Signature Omeprazole 20 mg is a highly regarded over-the-counter (OTC) medication, comparable to Prilosec OTC, designed to treat frequent heartburn occurring two or more days per week. It comes in delayed-release tablets, with a 42-tablet package providing three 14-day courses of treatment. The product is FSA eligible and known for its effectiveness in inhibiting acid production at the source. The omeprazole market, which includes brands like Kirkland Signature, is expected to grow significantly, with a projected CAGR of 6.4% from 2024 to 2036, reaching a market size of USD 2.38 billion by 2036. For more details, you can view the product information on their website.

Omeprazole OTC

Omeprazole OTC by Equate is a highly regarded brand, known for its effectiveness in treating heartburn and acid reflux. With a proven track record, Equate's omeprazole has been trusted by consumers since its introduction to the market. It is available in various strengths, including 20mg and 40mg capsules, and is often recommended for its affordability and efficacy. Studies have shown that omeprazole can provide relief for up to 80% of users within a week of consistent use. Equate's commitment to quality and customer satisfaction has made it a top choice among over-the-counter (OTC) medications. For more information, you can explore their offerings on the Walmart website.

Omeprazole OTC

CVS Health's omeprazole brand is a leading producer of omeprazole, offering effective relief from heartburn and acid indigestion. The CVS Health Omeprazole Delayed Release Acid Reducer Tablets, 20 MG, are comparable to Prilosec OTC and provide fast and reliable relief. With a high customer satisfaction rate, these tablets have a 4.8-star rating from 95 reviews. The market for omeprazole is expected to grow significantly, with the global omeprazole market projected to expand at a CAGR of 5.7% from 2024 to 2029. North America, where CVS Health operates, holds the largest market share, driven by the high prevalence of gastrointestinal disorders.

Omeprazole OTC

Omeprazole OTC by Walgreens is a highly regarded option for treating conditions like heartburn, GERD, and ulcers, with its delayed-release tablets available in 20 mg strengths. This product is part of a market expected to grow significantly, with the global omeprazole market projected to reach USD 2.38 billion by 2036, growing at a CAGR of more than 6.4%. The North American market, where Walgreens operates, is anticipated to hold the largest share of 59.3% during this forecast period. Omeprazole by Walgreens is also known for its affordability and effectiveness, with the capsule segment expected to occupy 52% of the market share by 2036. The product is available in various dosage forms, including delayed-release oral tablets and capsules, ensuring flexibility for patients. For more detailed information, you can view the full FDA drug information.

Omeprazole OTC

Rite Aid's Omeprazole OTC offers a highly effective treatment for frequent heartburn, available as 20mg delayed-release tablets that effectively reduce stomach acid production, providing significant relief from acid reflux and heartburn symptoms. Each bottle contains a 14-day course of treatment, with the option to take another course every 4 months. The tablets are both easy to swallow and manufactured in Israel. The omeprazole market, which includes Rite Aid's product, is expected to grow significantly, with a projected CAGR of 6.4% from 2024 to 2036, driven by increasing cases of chronic diseases and the proven effectiveness of omeprazole in treating conditions like GERD and H. pylori infections.

Omez

Dr. Reddy's Laboratories' Omez brand is a leading producer of omeprazole, offering high-quality capsules in various strengths, including 10 mg, 20 mg, and 40 mg. Launched in the US market in 2018, Omez delayed-release tablets are an over-the-counter (OTC) store-brand equivalent of Prilosec tablets, with combined market sales of around USD 492 million in the year ending October 2018. Omez is indicated for treating duodenal ulcers, gastric ulcers, reflux oesophagitis, and other gastrointestinal conditions, with omeprazole being more than 97% plasma protein bound. The omeprazole market, which includes Omez, is expected to grow at a CAGR of more than 6.4% from 2024 to 2036, driven by increasing cases of chronic diseases globally. Dr. Reddy's commitment to the OTC business and its extensive OTC portfolio further solidify Omez's position in the market. For detailed product information, refer to the approved prescribing information.

Omiprezole

Omeprazole Sandoz, produced by Sandoz, is a highly effective proton pump inhibitor, known for its efficacy in reducing stomach acid production by up to 70% after just 5 days of dosing with a 20 mg tablet. It is widely used to treat conditions such as reflux oesophagitis, peptic ulcers, and Zollinger-Ellison syndrome. The global omeprazole market, driven in part by Sandoz's products, is forecasted to grow to $3.15 billion by 2028, with a CAGR of 7.7%. Omeprazole Sandoz is available in various strengths, including 10 mg, 20 mg, and 40 mg gastro-resistant capsules, ensuring comprehensive treatment options. Its effectiveness and wide range of indications make it a leading choice in the market. For more detailed information, you can refer to the official product document.