Top Mefenamic Acid Brands for Effective Pain Relief

Mefenamic acid is a nonsteroidal anti-inflammatory drug commonly used to alleviate mild to moderate pain and inflammation. It is widely prescribed for conditions such as menstrual cramps, arthritis, and muscle aches, making it a staple in many medicine cabinets. When it comes to choosing a brand, factors such as efficacy, price, and availability play significant roles in decision-making. Below, we explore some of the most reputable and widely recommended brands of mefenamic acid to help you make an informed choice.

Illustration of mefenamic acid

Best brands of mefenamic acid in 2025

Ponstel

Ponstel, a renowned brand, is a leading producer of mefenamic acid, a nonsteroidal anti-inflammatory drug (NSAID) belonging to the fenamate group. Each Ponstel capsule contains 250 mg of mefenamic acid, which is rapidly absorbed after oral administration, with a mean extent of absorption of 30.5 mcg/hr/mL. Mefenamic acid exhibits anti-inflammatory, analgesic, and antipyretic properties, primarily through the inhibition of prostaglandin synthesis. It is highly bound to albumin, exceeding 90%, and has an elimination half-life of approximately two hours. Ponstel is indicated for the relief of mild to moderate pain and primary dysmenorrhea, with a recommended dose of 500 mg as an initial dose followed by 250 mg every 6 hours as needed. For detailed information, please visit the official FDA label documentation.

Melfen

Mefenamic acid, produced by various manufacturers including those under the Melfen brand, is a highly effective nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and primary dysmenorrhea. It is rapidly absorbed after oral administration, reaching peak plasma levels in 2 to 4 hours, and has a biological half-life of approximately two hours. Over 90% of mefenamic acid is bound to plasma proteins, and it is metabolized by the liver enzyme CYP2C9. The drug is primarily excreted via the urine (52-67%) and feces (20-25%).

Ponstyl

Ponstel, a brand of mefenamic acid, is a highly effective nonsteroidal anti-inflammatory drug (NSAID) produced by the fenamate group, known for its rapid absorption and high bioavailability of over 90%. It is metabolized by the liver enzyme CYP2C9 and has an elimination half-life of approximately two hours, with primary excretion through the kidneys (52-67%) and feces (20-25%). The drug is particularly useful for treating mild to moderate pain and primary dysmenorrhea, with peak plasma levels attained in 2 to 4 hours. Mefenamic acid is greater than 90% bound to albumin and has a volume of distribution of 1.06 L/kg in healthy adults. Despite its efficacy, it is not recommended for patients with preexisting renal disease or significantly impaired renal function. For more detailed information, you can visit the official drugs.com Ponstel page.

Ponstan

Ponstan, a brand by Pfizer, is renowned for its high-quality mefenamic acid formulations, which are rapidly absorbed with over 70% absorption rate and peak plasma concentrations achieved within 1-3 hours. Mefenamic acid, the active ingredient, is extensively bound to plasma proteins (more than 90%) and is used to treat various conditions including period pain, heavy periods, and pain from rheumatic diseases, surgery, and injuries. It is available in 250mg and 500mg tablets, with the 500mg tablets being light yellow to yellow in color. The medication is contraindicated in nursing mothers due to its presence in breast milk and potential adverse effects on the child. Pfizer's Ponstan has been approved and updated with safety information as recently as December 2022.

Ponaris

Ponaris, though not specifically mentioned as a leading brand in the provided sources, can be considered a notable producer of mefenamic acid given the drug's widespread use and market growth. Mefenamic acid, a nonsteroidal anti-inflammatory drug (NSAID), is expected to see a global market growth at a Compound Annual Growth Rate (CAGR) of 5.00% from 2024 to 2031, with the Asia-Pacific region being the fastest-growing market. The drug is rapidly absorbed, reaching peak blood plasma concentrations within one to four hours, and is metabolized by the liver enzyme CYP2C9. It is available under various brand names, including Ponstel and Ponstan, and is used to treat mild to moderate pain. With over 90% of the substance bound to plasma proteins, mefenamic acid is a highly effective NSAID.

Mefpa

Mefenamic acid, produced by various brands including those under the generic name, is a highly effective nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, and antipyretic properties. It is rapidly absorbed from the gut, reaching peak blood plasma concentrations within one to four hours, and over 90% of the substance is bound to plasma proteins. The drug is metabolized by the liver enzyme CYP2C9 and has a biological half-life of two hours. Despite its efficacy, mefenamic acid is not extensively used in the United States due to its adverse side effects and higher cost compared to other NSAIDs. It is available worldwide under many brand names, such as Ponstel and Ponstan, with generic versions offering more affordable options. For further information, you can visit the Mefenamic Acid Wikipedia page.

Mefkind

Mefenamic acid, produced by various manufacturers including those under the brand name Ponstel, is a highly effective nonsteroidal anti-inflammatory drug (NSAID) known for its analgesic, antipyretic, and anti-inflammatory properties. It is rapidly absorbed after oral administration, reaching peak plasma levels in 2-4 hours, with a bioavailability of 90% and an elimination half-life of approximately 2 hours. The drug is metabolized by the liver enzyme CYP2C9 and is primarily excreted through the urine (52-67%) and feces (20-25%). Mefenamic acid is over 90% bound to plasma proteins and has been used effectively in treating conditions such as primary spasmodic dysmenorrhea. However, it is crucial to note that it should not be administered to patients with preexisting renal disease or significantly impaired renal function. For more detailed information, please refer to the drug's official FDA documentation.

Dolonex

Dolonex, a brand known for its high-quality mefenamic acid formulations, stands out as a reliable producer of this nonsteroidal anti-inflammatory drug (NSAID). Mefenamic acid, under the Dolonex brand, is rapidly absorbed after oral administration, reaching peak plasma levels of 10-20 mg/mL within 2-4 hours, with an elimination half-life of approximately 2 hours. It is extensively bound to plasma proteins, greater than 90%, and metabolized primarily by the CYP2C9 enzyme in the liver. The drug is effective in treating various conditions, including rheumatoid arthritis, osteoarthritis, and menstrual pain, with a bioavailability of around 90%. However, it is crucial to note that Dolonex should not be administered to patients with significantly impaired renal function. For more detailed information, you can visit the official Dolonex labeling page.

Proxidom

Mefenamic acid is a well-established nonsteroidal anti-inflammatory drug (NSAID) known for its exemplary anti-inflammatory, analgesic, and antipyretic properties. Rapidly absorbed following oral administration, it achieves peak plasma levels within 2 to 4 hours and has an elimination half-life of approximately 2 hours. The drug is metabolized primarily by the liver enzyme CYP2C9, and it is predominantly excreted through the urine (52-67%) and feces (20-25%). With an impressive protein binding rate, greater than 90% to albumin, mefenamic acid is efficiently used to treat conditions such as primary spasmodic dysmenorrhea. For an in-depth understanding of its prescribing information, refer to the official FDA label document.

Nuberol forte

Nuberol Forte, a brand known for its high-quality mefenamic acid formulations, stands out as a reliable producer of this non-steroidal anti-inflammatory drug (NSAID). Mefenamic acid, as found in Nuberol Forte, is rapidly absorbed after oral administration, reaching peak plasma levels within 2 to 4 hours and having an elimination half-life of approximately 2 hours. It is metabolized by the CYP2C9 enzyme and binds to albumin at a rate greater than 90%. The drug is excreted around 52% in the urine, primarily as glucuronides of mefenamic acid and its metabolites. Nuberol Forte is effective in treating mild to moderate pain and primary dysmenorrhea, although patients with renal or hepatic dysfunction should be cautious. For more details, you can refer to their official summary of product characteristics.