Top Magnesium Threonate Brands for Optimal Brain Health

In recent years, magnesium threonate has gained popularity due to its potential cognitive benefits and role in supporting overall brain health. Consumers are increasingly turning to high-quality brands that prioritize purity and efficacy in their magnesium threonate supplements. Leading brands often dedicate their efforts to rigorous testing and sustainable sourcing to ensure their products meet the highest standards. To explore some of the top brands that stand out in the magnesium threonate market, see the list below.

Illustration of magnesium threonate

Best brands of magnesium threonate in 2025

Life Extension

Life Extension is a leading brand in producing high-quality magnesium L-threonate supplements, such as Neuro-Mag®, which has been shown to significantly improve cognitive and executive function in just 12 weeks, with a daily dose of 1.5 to 2 grams boosting magnesium levels in the cerebrospinal fluid by about 15% in 24 days. This form of magnesium, developed at MIT, is renowned for its ability to cross the blood-brain barrier, supporting brain plasticity and enhancing short-term and long-term memory. The supplement is available in both vegetarian capsules and a tropical punch flavored drink mix, making it convenient for various preferences. Life Extension's Neuro-Mag® has been praised for its effectiveness in supporting healthy memory and cognitive health, especially in adults aged 50-70. With over 300 biochemical reactions in the body dependent on magnesium, this supplement is a crucial addition for optimal brain health.

Jarrow Formulas

Jarrow Formulas is a renowned brand known for its high-quality magnesium supplements, particularly MagMind(r), which features Magtein(r), a patented form of Magnesium L-Threonate. This form of magnesium is uniquely effective in crossing the blood-brain barrier, significantly increasing brain magnesium levels, and supporting brain health, memory, and relaxation. Unlike typical forms of magnesium, where only about 5% reaches the brain, Magnesium L-Threonate demonstrates superior brain bioavailability. Jarrow Formulas' commitment to superior science and quality ingredients ensures purity and potency in every product, adhering to Current Good Manufacturing Practices (cGMP). Their formulations are backed by strong scientific research and funding of studies, making them a trusted choice for those seeking optimal health.

Doctor's Best

Doctor's Best is a renowned brand for producing high-quality magnesium supplements, particularly their Magnesium L-Threonate products, which are designed to support cognitive function, memory, and overall well-being. Their Brain Magnesium with Magtein, for instance, delivers 150 mg of magnesium per serving, supporting brain performance and synaptic stability. This formula is crafted with Magtein, a patented form of Magnesium L-Threonate, which has been shown to cross the blood-brain barrier effectively. Doctor's Best products are non-GMO, gluten-free, soy-free, and vegan, ensuring they are accessible to a wide range of consumers. With up to 6x better absorption than other forms of magnesium, Doctor's Best High Absorption Magnesium is a trusted choice for combating magnesium deficiency, which affects approximately 75% of Americans.

NOW Foods

NOW Foods is a renowned brand for producing high-quality magnesium supplements, particularly Magtein Magnesium L-Threonate, which is a patented form that readily crosses the blood-brain barrier to support brain health, memory, and learning. Each serving of Magtein contains 144 mg of magnesium, which is 34% of the daily value, and is available in 90 vegetarian and vegan-friendly capsules per container. This product is free from major allergens and is manufactured in a GMP facility. Magtein has been praised for its effectiveness in enhancing cognitive function and promoting a relaxed mood. It is distributed exclusively by AIDP, Inc. and is protected under several US patents.

Thorne Research

Thorne Research is renowned for its high-quality magnesium supplements, particularly magnesium threonate, which is valued for its ability to cross the blood-brain barrier and support brain health. Thorne's products are crafted with rigorous quality control, ensuring they are free from harmful ingredients and adhere to the FDA's guidelines for dietary supplements. The brand's collaborations with esteemed institutions like Mayo Clinic and Johns Hopkins underscore its commitment to excellence. With a "No List" policy, Thorne guarantees transparency and purity in their supplements. Approximately 75% of U.S. adults do not get enough magnesium from their diet, making Thorne's supplements a reliable choice.

Pure Encapsulations

Pure Encapsulations is a renowned brand in the health supplement industry, particularly noted for its high-quality magnesium threonate products like CogniMag. With over 30 years of research and development, Pure Encapsulations ensures its products are free from unnecessary additives, GMOs, and common allergens, and are manufactured in an NSF-GMP registered facility. Their magnesium-l-threonate, sourced from elemental ore magnesium and synthetic threonate, provides 72mg of magnesium per serving, which is 18% of the Daily Value. The brand's commitment to transparency and quality is evident in their third-party tested products and rigorous sourcing criteria. Pure Encapsulations' CogniMag has been clinically shown to enhance synaptic plasticity and cognitive function, particularly in individuals aged 50-70.

Source Naturals

Source Naturals is renowned for its high-quality magnesium L-threonate supplement, Magtein®, which has been shown in preclinical and clinical studies to support healthy memory, learning, and brain synapse density. Magtein® is a patented form of magnesium that may provide more magnesium to the brain than other forms, with benefits observed in tests of overall cognitive ability after 12 weeks of use. The recommended dosage is 3 capsules daily, preferably in divided doses. This supplement is free from common allergens like yeast, dairy, egg, gluten, soy, and wheat. Magtein® contains 144 mg of magnesium per serving, which is 36% of the daily value.

Double Wood Supplements

Double Wood Supplements is a renowned brand in the dietary supplement industry, particularly noted for its high-quality Magnesium L-Threonate products. Founded in 2013 by twin brothers Evan and Reese Wood, the company is committed to transparency, quality, and accessibility, manufacturing all its products in the USA in FDA-registered facilities that follow Good Manufacturing Practices (GMP). Their Magnesium L-Threonate, known as Magtein(r), is a bioavailable form that can cross the blood-brain barrier, supporting memory, cognitive function, and healthy sleep, with each serving providing 144 mg of elemental magnesium, which is 34.29% of the daily value. The products are third-party tested for purity and potency, ensuring customers receive effective and research-backed supplements. Double Wood Supplements is popular among those seeking to enhance cognitive function and overall health.

Dr. Mercola

Dr. Mercola's Magnesium L-Threonate is highly regarded for its superior absorption and cellular penetration, allowing it to cross the blood-brain barrier and support cognitive health, sleep quality, and muscle relaxation. Introduced with the patented Magtein formula, this supplement delivers 145 mg of magnesium per serving, which is 35% of the Daily Value (DV). Users have reported significant improvements in mental clarity, reduced anxiety, and enhanced sleep. Dr. Mercola has been providing quality products since 2001, and this magnesium supplement has shown remarkable benefits in studies, including a 9-year reduction in brain age over 12 weeks of supplementation. For further details, visit Dr. Mercola's Magnesium L-Threonate page on iHerb.

Designs for Health

Designs for Health is renowned for producing one of the best forms of magnesium threonate, known as Magtein®, which was developed by experts from the Massachusetts Institute of Technology and Tsinghua University in Beijing. This highly bioavailable form of magnesium is designed to cross the blood-brain barrier, making it uniquely effective for neurological functions. Each scoop of Designs for Health Magnesium Threonate provides 1 g of pure magnesium threonate, containing a minimum of 72 mg of elemental magnesium. This product is vegan-friendly, 100% pure, and free of excipients. It has been extensively researched in clinical studies to improve learning, memory, and neurological health. For more details, you can visit their Magnesium Threonate page.