Top Lubricant Eye Drop Brands: Comfort for Your Eyes

Finding the right lubricant eye drops can make a significant difference in comfort and eye health, especially for those who suffer from dryness or irritation. With a myriad of options available on the market, it can be challenging to determine which brands offer the best quality and efficacy. From renowned, trusted brands to innovative newcomers, the selection offers something for everyone, whether you're seeking relief from contact lens discomfort or computer-related eye strain. To help you make an informed choice, explore our comprehensive list of the best lubricant eye drop brands below.

Illustration of lubricant eye drops

Best brands of lubricant eye drops in 2025

Systane

Systane is a leading brand in the production of lubricant eye drops, known for its advanced and sophisticated products that provide high-performance dry eye symptom relief. For instance, Systane Ultra Lubricant Eye Drops offer extended protection and are clinically proven to deliver lasting relief for aqueous dry eye. The brand's portfolio includes a range of products such as Systane Complete, Systane Ultra, and Systane Balance, which are designed to address various types of dry eye conditions. These products have contributed significantly to the growth of the artificial tears market, which is expected to reach USD 4.30 billion by 2027, exhibiting a CAGR of 5.9% during the forecast period. Systane's innovative nano-droplet technology in products like Systane Complete ensures fast-acting hydration and long-lasting relief.

Refresh

Refresh brand is a leading producer of lubricant eye drops, known for its effective and fast-acting relief for dry, burning, and irritated eyes. Their products, such as REFRESH TEARS(r), instantly lubricate and moisturize the eyes, mimicking natural tears, and are available in preservative-free and multidose formats. According to the REFRESH (r) ECP Recommendation Survey in 2021, REFRESH (r) is the #1 Dr. Recommended Family of Products for preservative-free artificial tears. The brand's formulations, like REFRESH (r) DIGITAL, are specifically designed to address eye dryness caused by digital device use, protecting tears from evaporation due to incomplete blinking. With a strong presence in the market, Refresh brand continues to innovate and expand its product line to meet various individual needs and severity levels of dry eye syndrome.

TheraTears

TheraTears is a leading brand in the production of lubricant eye drops, renowned for its unique hypotonic and electrolyte-balanced formula that replicates healthy tears, providing immediate and long-lasting relief from dry eye symptoms. Developed by ophthalmologist Dr. Jeffrey P. Gilbard after 18 years of research, TheraTears is the fourth best-selling lubricant eye drop brand in drugstores and the fastest growing major lubricant eye drop brand in the US. It is available in over 50,000 retail locations across America and has the lowest osmolarity of any artificial tear on the market, making it highly effective in reducing dry eye inflammation. TheraTears contains the 5 vital electrolytes found in natural tears and is preservative-free in the eye, using a unique preserving ingredient that turns into pure oxygen and water on contact. With a strong market presence, TheraTears is a doctor-recommended solution for dry eye treatment. You can find more information about their TheraTears Dry Eye Therapy Lubricant Eye Drops online.

Blink

The Blink brand, acquired by Bausch + Lomb Corporation in 2023, is a leading producer of lubricant eye drops, enhancing the company's market share and product portfolio in the over-the-counter eye care industry. This acquisition has positioned Bausch + Lomb to address a broader range of consumer needs, particularly in the Asia Pacific region, which is expected to become the global market leader for eye drops by 2030. The global eye drops market, valued at USD 15.22 billion in 2022, is projected to grow to USD 23.11 billion by 2030 with a CAGR of 5.5%. Blink eye drops are known for their effectiveness in treating dry eye conditions, a prevalent issue among the growing geriatric population. The integration of Blink products has significantly expanded Bausch + Lomb's eye care offerings. For more information, visit the Blink eye drops page.

Biotrue

Biotrue, a brand under Bausch + Lomb, is renowned for its high-quality lubricant eye drops, particularly the Biotrue® Hydration Boost Lubricant Eye Drops, which are preservative-free and pH-balanced to match the natural tears of the eye. These drops, launched in 2021, contain hyaluronan (HA) and electrolytes to provide instant moisture relief for dry, digitally irritated eyes. The product is widely available at major U.S. retailers such as Walgreens, CVS, and Amazon, with a manufacturer's suggested retail price starting at $11.99. Biotrue's formulations are inspired by the biology of the eye, making them a preferred choice for those suffering from dry eye syndrome. The increasing demand for such products is driven by factors like prolonged digital device usage and an aging population.

GenTeal

The Genteal brand, offered by Alcon, is a leading producer of lubricant eye drops, particularly renowned for its effective solutions for mild, moderate, and severe dry eyes. Genteal Tears products contain active ingredients such as Hypromellose 2910 at 0.3% and Dextran 70 at 0.1%, providing significant relief for dry eye conditions. These products are available in various forms, including preservative-free vials, making them suitable for frequent use. The Genteal Tears Lubricant Eye Gel, with 0.3% Hypromellose, is another popular option for those needing extended hydration. This brand is favored by many due to its efficacy and the convenience of its packaging options. For more details, visit the eye drops and lubricants market report.

Bausch + Lomb

Bausch + Lomb is a leading producer of lubricant eye drops, known for its innovative products such as Biotrue® Hydration Boost Lubricant Eye Drops, which offer immediate moisture and relief for irritated, dry eyes. The company has a significant market share, with North America accounting for 37% of the overall eye drop and lubricants market in 2021. Bausch + Lomb has also made strategic acquisitions, including the purchase of Xiidra from Novartis for up to $2.5 billion, enhancing its portfolio in treating dry eye disease. Their products are designed to address various facets of dry eye, positioning the company as a leader in ocular surface diseases. With a strong focus on R&D and product launches, Bausch + Lomb continues to expand its offerings and market presence.

Optive

The Optive brand, offered by Allergan, is renowned for its high-quality lubricant eye drops, providing long-lasting relief from dry eye symptoms. Introduced in 2006, Optive Lubricant Eye Drops feature a dual-action formula that lubricates and hydrates the eye, with clinical trials showing statistically significant improvement in six signs and symptoms of dry eye. The preservative-free version, Optive Sensitive, launched in 2008, is particularly beneficial for patients post-LASIK surgery, reducing ocular surface staining and dry eye symptoms. These products have demonstrated superior efficacy compared to other brands like Systane, with nearly five times more patients needing to administer Systane within an hour to relieve dry eye symptoms. The Optive brand's effectiveness and patient compliance have made it a leading choice in the ophthalmic market. For more information about Optive Lubricant Eye Drops, visit their website.

Retaine

Retaine MGD by OCuSOFT is a highly regarded brand for lubricant eye drops, particularly effective for dry eye disease and aqueous deficient dry eye. These preservative-free drops utilize a proprietary oil-in-water emulsion technology with electrostatic attraction to restore the three layers of the tear film, providing long-lasting comfort and reducing tear evaporation. With a lipid-replenishing formula, they contain 0.5% mineral oil and light mineral oil as emollients. Customers have rated these drops highly for effectiveness and ease of use, with many preferring them over other brands like Hylo Forte. The product is available in 30 sterile single-dose containers, each containing 0.4 mL of the emulsion. For more information, visit the Retaine MGD product page.

Clear Eyes

Clear Eyes is a leading brand in the production of lubricant eye drops, known for its effective relief from redness, dryness, and irritation. Their Redness Relief Eye Drops contain naphazoline hydrochloride 0.012% and glycerin 0.25%, providing up to 12 hours of soothing comfort and protecting against further irritations. The Clear Eyes Natural Tears Lubricant Eye Drops feature ingredients found in natural tears, offering daily moisturizing comfort and relief from mild dry eyes. With a strong presence in the OTC dry eye drops market, which is projected to grow at a 7.6% CAGR from 2024 to 2032, Clear Eyes continues to be a trusted choice for eye care. The brand's products are widely available and recommended for their efficacy in managing eye irritations.