Top Loperamide Brands for Effective Relief

Loperamide is a commonly used medication for controlling diarrhea, and several brands have established a reputation for their efficacy and reliability in delivering this remedy. Among the top brands offering loperamide products are Imodium, renowned for its fast-acting relief; Equate, which provides an affordable yet effective alternative; and HealthA2Z, known for its quality and consistency. Additionally, Kirkland Signature, the Costco brand, is noted for offering excellent value. To explore the benefits and specifications of each of these leading brands, please continue reading below.

Illustration of loperamide

Best brands of loperamide in 2025

Imodium

Imodium, a brand developed by Dr. Janssen and launched in 1973, is one of the leading producers of loperamide, a long-acting antidiarrheal medication. Imodium products, such as Imodium Multi-Symptom Anti-Diarrheal Relief and Imodium A-D Anti-Diarrheal Oral Solution, are widely recognized for their effectiveness in controlling nonspecific and chronic diarrhea. These products have been trusted globally for over 40 years, providing relief from symptoms like gas, bloating, and cramps. The FDA-approved Imodium A-D is available over-the-counter and has a maximum daily dose of 8 mg for adults, with prescription use allowing up to 16 mg per day. Imodium's products are designed to slow intestinal motility, reducing electrolyte loss and providing quick relief.

Diamode

Loperamide, commonly known by the brand name Imodium, is a widely used antidiarrheal medication produced by several manufacturers, including Johnson & Johnson. It is one of the most prescribed medications for diarrhea, with over 700,000 prescriptions in the United States in 2021, making it the 287th most commonly prescribed medication that year. Loperamide is effective in managing acute diarrhea by slowing intestinal movement, and it is available both over-the-counter and by prescription. The FDA has implemented packaging limits to ensure safe use, restricting each carton to no more than 48 mg of loperamide. Despite its efficacy, high doses can lead to severe heart rhythm problems and death.

Anti-Diarrheal

Loperamide, a key component in anti-diarrheal medications, is predominantly produced by several leading pharmaceutical companies, with brands like Imodium being among the most trusted. The global antidiarrheal drug market, which was valued at around USD 100.05 billion in 2023, is expected to grow at a CAGR of 4.88% to reach USD 152.02 billion by 2032. North America holds a significant market share, with over 40% of the global revenue, driven by the high prevalence of diarrhea and the widespread use of over-the-counter medications like loperamide. The motility-modifying drugs segment, which includes loperamide, holds the largest market share due to its efficacy in managing acute diarrhea. Companies such as Pfizer, Inc., and Perrigo are among the leading players in this market.

Loperamide HCl by McKesson

Loperamide HCl by McKesson brand is a highly effective anti-diarrheal medication, clinically proven to control and provide symptomatic relief for acute non-specific diarrhea, including Travelers' Diarrhea. Each caplet contains 2 mg of Loperamide HCl, and the recommended dosage varies by age and weight. For adults and children over 12 years, the initial dose is 2 caplets after the first loose stool, followed by 1 caplet after each subsequent loose stool, not exceeding 4 caplets in 24 hours. This medication is available in various forms, including capsules, tablets, and oral solutions, ensuring flexibility for different patient needs. It is crucial to follow the dosage instructions carefully to avoid serious heart problems associated with overdose. For more detailed information, visit the McKesson product page.

Equate Anti-Diarrheal

Equate Anti-Diarrheal Tablets, containing 2 mg of loperamide HCl per capsule-shaped tablet, are a highly effective option for controlling symptoms of diarrhea, including Traveler's Diarrhea. This product, comparable to Imodium A-D, is designed for adults and children 6 years and older, with clear dosage guidelines to ensure safe and effective use. Equate Anti-Diarrheal Tablets are part of the broader loperamide market, which is expected to grow significantly in the coming years. The product is available in a 24-count package and emphasizes the importance of drinking clear fluids to prevent dehydration. With its reliable formulation and user-friendly instructions, Equate Anti-Diarrheal Tablets provide comfort and relief from diarrhea symptoms. For more details, visit the Equate Anti-Diarrheal Tablets product page.

Walgreens Anti-Diarrheal

Walgreens is a prominent producer of anti-diarrheal medications, particularly its Loperamide Hydrochloride products, which are highly recommended by pharmacists. The Walgreens brand of Loperamide HCl tablets and oral solutions is designed to control symptoms of diarrhea, including travelers' diarrhea, with each caplet containing 2 mg of the active ingredient. The market for Loperamide HCl is growing at a moderate pace, with significant growth rates expected in the forecasted period from 2020 to 2027. Walgreens' anti-diarrheal products are available in various forms, such as tablets and oral solutions, and are known for their effectiveness and customer satisfaction. The company ensures high-quality products, with a 100% satisfaction guarantee.

Kirkland Signature Anti-Diarrheal

The Kirkland Signature Anti-Diarrheal brand, produced by Costco Wholesale Company, is a highly regarded option for loperamide, a common anti-diarrheal medication. This OTC drug, with an active ingredient strength of 2 mg per tablet, has been on the market since 2003 and is part of the broader global antidiarrheal drug market, which is projected to grow at a CAGR of 5.20% from 2024 to 2031. Loperamide, the primary component, works by slowing intestinal movement and reducing bowel movements. The FDA has emphasized the importance of using loperamide as directed to avoid serious heart problems, with a maximum approved daily dose of 8 mg for OTC use. Kirkland Signature Anti-Diarrheal is one of several store brands and generics available, offering a reliable and affordable solution for managing diarrhea symptoms.

CVS Health Anti-Diarrheal

CVS Health Anti-Diarrheal Tablets, containing loperamide hydrochloride, are a reliable and effective option for relieving diarrhea symptoms. Loperamide, the active ingredient, acts as a peripheral mu-opioid receptor agonist to slow intestinal motility and increase water and electrolyte absorption. This product is part of a market that has seen significant growth, driven by increasing awareness of antidiarrheal drugs with fewer side effects and rising prevalence of diarrhea cases. The FDA has approved loperamide for controlling symptoms of diarrhea, with a maximum daily dose of 8 mg for OTC use, and it is widely available, including through CVS's free delivery service for orders over $35. This product is also part of the broader loperamide market expected to grow substantially from 2020 to 2027. For more detailed information, you can explore the CVS Health Anti-Diarrheal Tablets.

Amazon Basic Care Anti-Diarrheal

Amazon Basic Care Anti-Diarrheal, containing loperamide HCl, is a highly effective and safe OTC medication for controlling symptoms of diarrhea, including Travelers' Diarrhea, when used as directed. Each caplet or capsule contains 2 mg of loperamide HCl. The FDA has implemented packaging changes to limit each carton to no more than 48 mg of loperamide to prevent abuse and misuse, particularly since 2019. The drug acts on opioid receptors in the gut to slow intestinal motility, with a high protein binding of about 95% and an elimination half-life of approximately 10.8 hours. It is crucial to follow the recommended dosing to avoid serious heart problems and other adverse effects. For more detailed information, visit the FDA DailyMed website.

Sunmark Anti-Diarrheal

Sunmark Anti-Diarrheal caplets, comparable to Imodium A-D, are a reliable option for controlling symptoms of diarrhea, including Traveler's Diarrhea, with each caplet containing 2 mg of loperamide. This medication acts by decreasing peristalsis and fluid secretion in the gastrointestinal tract, providing quick relief. The FDA has emphasized the importance of using loperamide at the recommended doses to avoid serious heart problems, highlighting the safety of the drug when used as directed. In the global antidiarrheal drug market, which was estimated at USD 102,154.2 million in 2024, products like Sunmark Anti-Diarrheal contribute to the market's growth, expected to expand at a CAGR of 5.2% from 2024 to 2031. Sunmark Anti-Diarrheal caplets are suitable for adults and children 6 years and older, with specific dosing instructions to ensure safe use. For detailed product information, visit their official product page.