Top Ketoconazole Shampoos: Leading Brands for a Healthier Scalp

Ketoconazole shampoo has gained popularity as a powerful solution for dandruff and various scalp issues. Its antifungal properties help in reducing itchiness and flakiness, making it a favorite choice among individuals seeking a healthier scalp. With numerous brands offering ketoconazole shampoo, choosing the right one can be overwhelming. Below, we explore some of the top brands that stand out for their quality and customer satisfaction.

Illustration of ketoconazole shampoo

Best brands of ketoconazole shampoo in 2025

Nizoral

Nizoral, a globally recognized brand, is a leading producer of ketoconazole shampoo, known for its effectiveness in treating fungal infections such as dandruff, redness, and itchiness of the scalp. With a market share several times that of its nearest competitor in the EMEA region, Nizoral solidifies its position as the clear market leader among medicated anti-dandruff shampoos. In 2017, Nizoral generated sales of approximately EUR 33 million in the EMEA region, with over 50% of these sales coming from Russia, Italy, Great Britain, Poland, and the Middle East. The shampoo's long duration of effectiveness, up to seven days, makes it highly effective against persistent dandruff. ANI Pharmaceuticals has recently launched a generic version of Nizoral's ketoconazole shampoo, entering a market with annual sales of approximately $69.2 million in the U.S.

Head & Shoulders Clinical Strength

Head & Shoulders Clinical Strength is a leading brand in producing effective dandruff shampoos, often compared to prescription-strength ketoconazole shampoos. Their formulas, such as the Clinical Strength Dandruff Defense + Advanced Oil Control Shampoo, contain 1% Selenium Sulfide, providing prescription-strength flake protection equivalent to 2% ketoconazole shampoos. These shampoos offer up to 100% dandruff protection with regular use and are clinically proven to fight Malassezia after just one wash. They are highly effective in treating severe dandruff and seborrheic dermatitis, and are recommended by dermatologists. The brand's products have been trusted for decades, making them a reliable choice for scalp health.

Regenepure DR

Regenepure DR is a highly regarded brand for ketoconazole shampoo, particularly effective in combating hair loss and treating scalp conditions. The shampoo contains 1% ketoconazole, which has been clinically proven to improve hair density and size, as well as reduce sebum levels and inhibit DHT. It also includes other beneficial ingredients like saw palmetto, caffeine, and emu and jojoba oils to nourish and strengthen hair. Free from SLS, parabens, and harsh chemicals, it is suitable for all hair types, including color-treated and keratin-treated hair. Recommended usage is 3-4 times a week to avoid dryness.

Sebclair

Sebclair is a non-steroidal range specifically designed to manage the signs and symptoms of seborrhoeic dermatitis (SD) and cradle cap, boasting anti-inflammatory and antifungal properties. Sebclair shampoo includes key ingredients like Piroctone Olamine, Acifructol, and Shea Butter, known for its excellent safety profile and absence of rebound effects common with topical corticosteroids. Available as both a shampoo and cream, Sebclair is clinically supported as a first-line treatment for seborrheic flares and long-term maintenance. Unlike ketoconazole shampoos, Sebclair does not contain this active ingredient, distinguishing it from other anti-dandruff treatments like Nizoral, which dominate over 30% of the dandruff treatment market share in 2023.

Sebozol

Sebizole, a renowned brand, offers a highly effective ketoconazole 2% shampoo for the treatment of severe seborrheic dermatitis and dandruff, providing temporary relief with a significant mycological clearing rate of 84% and 78% for three-day and one-day regimens, respectively. This shampoo targets the underlying yeast cause, inhibiting the growth of dermatophytes and yeasts, and is recommended for use twice a week for 2 to 4 weeks, with a 4-week break between treatments. It is safe and well-tolerated, with adverse events occurring in less than 1% of patients. Sebizole shampoo is also noted for its low irritancy potential compared to other medicated shampoos. The product is available in a 200ml formulation. For more details, visit the Sebizole Ketoconazole 2% Medicated Shampoo page.

DS Laboratories Dandrene

DS Laboratories' Dandrene brand is renowned for its effective anti-dandruff and scalp care products; although it does not specifically feature ketoconazole in its Dandrene line, these products utilize salicylic acid 2% and activated charcoal to address chronic scalp conditions like psoriasis, seborrheic dermatitis, and common dandruff. Developed by world-class dermatologists, these formulations are clinically proven and gentle for daily use, providing instant oil control and hydration. The Dandrene shampoo and conditioner work synergistically to control and prevent dandruff recurrence and are recommended by dermatologists for their efficacy. Founded in 2007, DS Laboratories is a technology company focused on innovation in hair and skincare.

Revita by DS Laboratories

Revita Shampoo by DS Laboratories is a highly effective and clinically tested ketoconazole shampoo, containing 1% ketoconazole, which has been proven to strengthen hair, increase hair density, and reduce hair loss. In clinical studies involving 500 participants, 90% experienced a decrease in hair loss, 85% saw an overall improvement in hair appearance, and 70% reduced their hair loss rate. This shampoo is free of harsh chemicals, sulfates, parabens, and gluten, making it suitable for all hair types, including color-treated hair. It also includes additional ingredients like caffeine, biotin, and procyanidin B2 to enhance hair growth. Recommended by top dermatologists and hair professionals worldwide, Revita Shampoo has been a trusted choice for over 10 years.

Ketozal

Ketozal is a reputable brand for ketoconazole shampoo, particularly known for its 2% ketoconazole formulation, which is effective in treating severe cases of dandruff and seborrheic dermatitis. This prescription-strength shampoo, manufactured by Chemax Pharma, has been shown to produce excellent results in as little as 2 to 4 weeks, with a clinical response rate of up to 88% in patients. Ketozal 2% ketoconazole shampoo is often compared to Nizoral in terms of efficacy and is considered a more affordable, generic alternative. The shampoo is easy to use and comes in a 60ml bottle with a flip-top cap. It is recommended to use an intensive conditioner after application, especially for dry hair.

Selsun Blue

Selsun Blue, although not a primary producer of ketoconazole shampoos, is a well-known brand in the medicated shampoo market, particularly for its selenium sulfide-based products. However, ketoconazole shampoos, such as those from the Nizoral brand, dominate the market with a 30% share in the dandruff treatment segment as of 2023. Ketoconazole shampoos are favored for their effective antifungal properties and broad acceptance among dermatologists and consumers. The global ketoconazole market is expected to grow at a CAGR of 4.6% from 2024 to 2031, driven by increasing demand for antifungal therapies. Ketoconazole shampoos are widely available over-the-counter, contributing to their popularity.

Keto-plus

Ketoconazole shampoo from reputable brands like Nizoral, often associated with the active ingredient ketoconazole, is highly effective in treating fungal infections such as dandruff, seborrheic dermatitis, and tinea versicolor. The 2% ketoconazole solution has been FDA-approved and is available in both over-the-counter (OTC) and prescription strengths. Studies have shown mycological clearing rates of 84% and 78% for three-day and one-day regimens, respectively, highlighting its efficacy. The shampoo is generally safe to use, with minimal systemic absorption, and is suitable for individuals aged 12 and above. However, it may cause side effects such as itching, dry skin, and hair discoloration in some users.