Top Dihydroberberine Brands for Optimal Health Boost

Dihydroberberine, a powerful supplement renowned for its potential health benefits, is gaining popularity among health enthusiasts and wellness communities. With its enhanced bioavailability over traditional berberine, many brands are emerging to offer high-quality options. Each brand varies in terms of sourcing, formulation, and pricing, making it essential for consumers to choose wisely. Join us as we explore and compare some of the best brands for dihydroberberine below.

Illustration of dihydroberberine

Best brands of dihydroberberine in 2025

Designs for Health

Designs for Health is renowned for producing high-quality dihydroberberine (DHB) supplements, leveraging the enhanced bioavailability of DHB, which is absorbed 5 to 10 times better than traditional berberine. This improved absorption is due to the chemical modification that makes DHB more lipophilic, allowing it to cross biological membranes more effectively. DHB from Designs for Health is formulated to reduce gastrointestinal side effects commonly associated with berberine, making it a safer and more tolerable option for long-term use. By activating AMPK and modulating the mTOR pathway, DHB from Designs for Health supports metabolic health, insulin sensitivity, and cellular senescence reduction. This formulation has been shown to achieve significantly higher plasma concentrations of the active ingredient compared to standard berberine.

Thorne Research

Thorne Research is renowned for its high-quality dietary supplements, including its Berberine-500 formula, which, although not specifically dihydroberberine, showcases the brand's commitment to using pure natural sources and advanced formulations. Thorne Research Berberine-500 contains 500 mg of berberine per capsule, supporting cardiovascular health by reducing cholesterol and triglyceride levels while increasing HDL cholesterol. This formula is gluten-free and manufactured in facilities that adhere to current Good Manufacturing Practices (cGMP). The product is designed to improve cellular functions and promote healthy metabolism, making it a trusted choice for those seeking nutritional support. With its rigorous quality control and use of berberine from Indian Barberry extract, Thorne Research stands out as a reliable producer in the supplement industry. For more information, visit the Thorne Research Berberine-500 page.

Pure Encapsulations

Pure Encapsulations is not specifically mentioned in the provided sources as a producer of dihydroberberine, but it is known for its high-quality supplements. However, for dihydroberberine, brands like Double Wood Supplements and Fullscript feature highly bioavailable forms. Double Wood Supplements' dihydroberberine is noted for its greater plasma concentrations compared to standard berberine, with a 100mg dose of dihydroberberine producing significantly greater plasma concentrations than a 500mg dose of berberine. Fullscript's Dihydroberberine SR, featuring GlucoVantage® dihydroberberine, offers a sustained-release formula that dissolves over 5 to 7 hours.

Life Extension

Life Extension is a renowned brand that has been delivering high-quality, science-backed supplements for over 40 years, with a strong focus on health and wellness. They are highly recommended, with 98% of their customers endorsing the products to family and friends. Life Extension's berberine supplements, such as Berberine Phytosome, offer enhanced absorption and potency, supporting healthy blood sugar metabolism, cardiovascular health, and immune function. Their commitment to sustainability and anti-aging research further solidifies their reputation as a trusted provider of nutritional benefits. With a wide range of berberine products, including Berberine 1200 and Berberine 1000, Life Extension ensures that customers receive the best supplements available.

Dr. Mercola

Dr. Mercola's brand is renowned for its high-quality supplements, including the Berberine and MicroPQQ Advanced, which combines berberine and pyrroloquinoline quinone (PQQ) to enhance mitochondrial health and metabolic function. Berberine, a key ingredient, has been shown to lower blood sugar by 20% and HbA1c by 12% in clinical studies, and it may be as effective as certain oral diabetes medications. Dr. Mercola's products are non-GMO, lab-tested for safety, and made from ethically sourced ingredients, ensuring a commitment to holistic wellness and environmental sustainability. The Berberine and MicroPQQ Advanced supplement features a patented form of MicroPQQ that is twice as effective as standard PQQ, with 10mg equivalent to 20mg of other PQQ supplements. Dr. Mercola, an osteopathic physician, has been a pioneer in natural health since the 1990s, offering over 1,000 high-quality supplements.

Swanson Health

Swanson Health is a renowned brand in the health supplement industry, particularly noted for its high-quality berberine products. Swanson's Berberine HCl, derived from the root of Berberis aristata, has been shown to positively impact sugar-insulin metabolism, reduce bad cholesterol by up to 26% in 12 weeks, and support weight loss when combined with a reduction diet and physical activity. The supplement is available in 400 mg capsules, with a recommended daily serving of one capsule, and is sufficient for two months. Berberine from Swanson Health has also been recognized for its potential as an anti-diabetic medication, improving insulin sensitivity by 33%. With a growing market projected to reach USD 2.1 billion by 2033, Swanson Health remains a key player in the berberine supplements market.

Jarrow Formulas

Jarrow Formulas is a renowned leader in the dietary supplement industry, known for its high-quality and science-backed products, including dihydroberberine. With over 50 years of experience, Jarrow Formulas ensures precision manufacturing, comprehensive analysis, and temperature-controlled distribution to maintain the highest standards of quality assurance. Their state-of-the-art laboratories test raw materials and finished products for identity, chemical, microbiological, and other properties, adhering to cGMP and organic certification standards. This commitment to quality has earned them industry awards for nearly two decades. Jarrow Formulas' products are trusted by customers for their efficacy and safety.

NOW Foods

NOW Foods stands out as a reliable and high-quality producer of berberine supplements, as evidenced by their rigorous testing program. In their December 2023 testing, NOW Foods was the only brand to achieve 100% potency, while 18 out of 33 other brands tested contained less than 40% of the labeled potency. This consistency in quality is a result of their stringent manufacturing standards and third-party testing through Alkemist Labs. NOW Foods has been conducting such tests since 2017, highlighting their commitment to transparency and consumer safety. Their berberine supplements, such as the Berberine Glucose Support, are formulated to optimize metabolism naturally and ensure optimal absorption. For more details about their products, visit their supplements page.

Nutricost

Nutricost is renowned as one of the best producers of dihydroberberine supplements, offering high-quality products with precise dosages, such as 100 mg and 200 mg per capsule, ensuring consistency and efficacy. Their dihydroberberine capsules are designed for healthy individuals 18 years and older, with recommendations to consult a healthcare professional if pregnant, nursing, or taking medication. Nutricost's commitment to quality is evident in their 60-day money-back guarantee and efficient shipping, with orders typically processed within 1-2 business days. The brand's products are available through various online platforms, highlighting their widespread accessibility. With a focus on customer satisfaction, Nutricost stands out in the supplement market.

Douglas Laboratories

Douglas Laboratories is a renowned brand in the supplement industry, particularly noted for its high-quality and scientifically-backed products, including those featuring dihydroberberine. With over 60 years of experience, Douglas Laboratories has established itself as a leader in developing innovative supplements that support various health needs, such as cardiometabolic health. Their Berberine Balance supplement combines berberine with alpha lipoic acid and grape seed extract to support healthy blood sugar and cardiovascular health. This formulation is available in 60 vegetarian capsules per container, with each serving providing 500 mg of berberine HCl. Douglas Laboratories' commitment to quality and efficacy makes it a trusted choice among healthcare practitioners and health-conscious consumers.