Top Argireline Brands to Explore in Skincare Innovation

Argireline, often referred to as "Botox in a bottle," is a popular peptide used in skincare products for its anti-aging benefits. Renowned for reducing the appearance of fine lines and wrinkles, its demand has surged as consumers seek non-invasive solutions for youthful skin. Numerous brands have embraced Argireline in their formulations, offering a range of products that cater to different skin needs and preferences. If you're curious about which brands have excelled in harnessing the power of Argireline, explore the list below for some of the best options available.

Illustration of argireline

Best brands of argireline in 2025

The Ordinary

The Ordinary is a leading brand in skincare, renowned for its effective and affordable formulations, notably their Argireline Solution 10%, which contains a potent 10% concentration of Acetyl Hexapeptide-8, a peptide complex clinically shown to target dynamic lines and wrinkles, especially around the eyes and forehead. This lightweight, water-based serum is designed for daily use, morning and night, before heavier treatments to improve the appearance of fine lines and sagging skin, and comes in a 30ml bottle. The Ordinary's Argireline solution offers a non-invasive approach to reducing the appearance of expression lines and is a cruelty-free, vegan option, utilizing a trademarked solution from Lipotec.

NIOD

NIOD is a leading brand in skincare science, recognized for its advanced formulations, including products with Argireline, a peptide known to target expression lines. Their *Fractionated Eye-Contour Concentrate* utilizes a SNAP-25 pentapeptide-18 complex, considered more effective than Argireline alone. Meanwhile, other NIOD products, such as *Copper Amino Isolate Serum*, contain different innovative peptide complexes. NIOD emphasizes research and technology, developing products to address concerns from aging to skin sensitivity, aiming for transformative results. Although NIOD's *Fractionated Eye-Contour Concentrate* does not specifically disclose the exact percentage of Argireline, it is considered a sophisticated formulation with multiple technologies designed to combat wrinkles and dark circles. You can explore their products for more information.

Matrixyl

Matrixyl, a brand by Sederma, which was acquired by Croda Beauty in 1997, is a well-known producer of peptides, including Matrixyl 3000, which stimulates collagen production, and is often combined with Argireline, a peptide that can reduce wrinkles by inhibiting muscle contractions, with some studies showing a 27% wrinkle reduction after 30 days of use, and a typical concentration for Argireline being between 5-10% in serums. Matrixyl was initially created in 2000 as a synthetic peptide to boost collagen production and has been used in over 1500 products globally. Matrixyl and Argireline are often found in serums with hyaluronic acid and vitamin C to improve skin hydration, elasticity, and overall appearance; many products combine the two with concentrations reaching 20% of Argireline. You can find more information about Matrixyl.

Timeless Skin Care

Timeless Skin Care is a notable brand, producing effective skincare serums, including their Matrixyl 3000 serum, which contains an 8% concentration of Matrixyl 3000 and is known for boosting collagen and improving skin texture, as well as their argireline serums that target fine lines. Their products often feature hyaluronic acid for added hydration and are considered a great value, with many users reporting positive results. The brand is praised for its simple, effective formulas.

Peter Thomas Roth

Peter Thomas Roth is a leading brand in skincare, known for its Peptide Skinjection Amplified Wrinkle-Fix Serum, which features a powerful 19% peptide complex including Argireline, and is further enhanced with 10% Argirelox, clinically proven to help reduce the appearance of expression lines and prolong the need for injectables by up to six months, with visible improvements to fine lines and wrinkles within just one week of use. This product, released in 2023, is available in a refillable format. You can find more details at Peter Thomas Roth Peptide Skinjection Amplified Wrinkle-Fix Serum.

Dr. Brandt

Dr. Brandt is a prominent skincare brand known for its innovative formulations, including argireline, which is often featured in their anti-aging products, such as their Triple Peptide Eye Cream, to help reduce the appearance of fine lines and wrinkles by stimulating collagen production and relaxing facial muscles, with some formulations containing 5-10% concentration of argireline for optimal results, and the brand focuses on combining science and dermatology to create effective skincare solutions. You can explore their products further at Dr. Brandt Skincare.

SkinCeuticals

SkinCeuticals, a leading skincare brand since its founding in 1997, is renowned for its advanced formulations, often incorporating a potent 10% concentration of argireline, a peptide that can reduce the appearance of wrinkles. Their dedication to scientific research and high-quality ingredients, along with rigorous clinical testing, has made them a popular choice. With products designed to target specific signs of aging, including fine lines and wrinkles, SkinCeuticals continues to innovate and deliver effective solutions. You can explore their range of argireline products for yourself.

SkinMedica

SkinMedica, a brand established by physicians over 20 years ago, is known for its science-backed approach to skincare, offering products like the TNS Essential Serum with a 93.6% concentration of growth factors, which helps to tighten skin and reduce wrinkles, while other products combine peptides and argireline to boost collagen. They are often recommended by dermatologists as a good alternative to Botox, with the TNS Advanced+ Serum clinically proven to smooth fine lines and target sagging, and many of their products are designed to complement in-office treatments for enhanced results.

Paula's Choice

Paula's Choice is a well-regarded skincare brand that incorporates argireline, also known as acetyl hexapeptide-8, into some of its formulations, leveraging its ability to help reduce the appearance of expression lines, with research also suggesting it can support skin's collagen and firmness. While they do not have a dedicated argireline serum, their Calm Rescue and Repair Weightless Moisturizer includes this peptide, and they emphasize well-formulated products that allow for better ingredient penetration into the skin. The Ordinary also offers an Argireline Solution 10% serum.

Derma-nu

Derma-nu is a producer of skincare products, with a focus on organic and natural ingredients, often incorporating advanced, clinically-proven elements; they formulate their products in small batches in their registered laboratory, ensuring maximum potency, purity, and efficacy, and while they use mostly organic ingredients, they use some non-organic ingredients when necessary for product stability, and are known for combining active natural and organic plant extracts to repair and beautify the skin. While they don't specify the exact percentage of Argireline in their products, most serums feature between 5-10% of Argireline. You can find more information about their skincare products.