Top Methylfolate Brands for Optimal Wellness

Methylfolate supplements have become increasingly popular as more people seek ways to support their mental and physical health. With so many brands on the market, choosing the right one can be overwhelming. It's important to consider factors such as the purity of the ingredients, the reputation of the brand, and customer reviews when making your choice. Below, we explore some of the best brands offering high-quality methylfolate supplements, helping you make an informed decision.

Illustration of methylfolate

Best brands of methylfolate in 2025

Thorne Research

Thorne Research is a highly regarded brand for methylfolate supplementation, known for its high-quality and bioavailable products. Their 5-MTHF supplement, formulated with Gnosis S.p.A.'s L-5-Methyltetrahydrofolate (Extrafolate-S(r)), provides 1,700 mcg of dietary folate equivalent per 1mg capsule, supporting heart, brain, and blood health. This supplement is particularly beneficial for individuals with genetic difficulties in converting folic acid to its active form, affecting up to three out of five Americans. Thorne's products are free from gluten, artificial fillers, dyes, and additives, and are manufactured in third-party certified facilities. The recommended dose is one capsule one to two times daily, or as advised by a healthcare practitioner.

Jarrow Formulas

Jarrow Formulas is renowned as one of the best producers of methylfolate due to its commitment to superior science and quality ingredients. Their methylfolate products, such as Quatrefolic(r), represent the 4th generation in folate delivery, ensuring high bioavailability and stability. Jarrow Formulas adheres to Current Good Manufacturing Practices (cGMP) and conducts comprehensive analysis in state-of-the-art laboratories to ensure purity and potency. Their formulations are crafted with expertise from global researchers and institutions, supporting optimal health. With products like Methyl Folate 1000 mcg, they offer a highly biologically active form of folate, essential for cellular energy metabolism and neurotransmitter synthesis.

Solgar

Solgar is renowned as one of the best producers of methylfolate supplements, offering high-quality products like Solgar Folate Metafolin 1000mcg, which contains the bioavailable form of folic acid, l-methylfolate, ensuring maximum absorption and supporting energy production, cardiovascular health, and the formation of healthy red blood cells. Founded in 1947, Solgar has a long-standing commitment to using non-GMO ingredients and avoiding artificial additives, making their supplements a trusted choice for health and well-being. Their products are crafted in small batches to ensure freshness and are produced using filtered water. Solgar's Metafolin formulation is particularly beneficial for individuals who have difficulty converting folic acid into its active form. This supplement is also crucial for preventing birth defects and supporting fertility.

Pure Encapsulations

Pure Encapsulations is renowned for producing high-quality methylfolate supplements, utilizing the universally metabolized and biologically active form of folate known as 5-methyltetrahydrofolate (5-MTHF). Their products, such as Folate 1000 and Folate 5000, provide superior bioavailability, bypassing enzymatic activation steps, which is particularly beneficial for individuals with genetic variations in the MTHFR gene, affecting over half of the US population. These supplements are made with hypoallergenic, vegan ingredients and are free from common allergens and unnecessary additives. The Folate 5000 Plus, for example, offers 5,000 mcg of activated folate per capsule, supporting cellular, cardiovascular, neurological, and psychological health. Pure Encapsulations' commitment to verifiable science and high-quality ingredients makes them a trusted brand in the dietary supplement industry. You can explore their Folate 1000 supplement for more detailed information.

Life Extension

Life Extension is a renowned brand that has been delivering high-quality, science-backed supplements for over 40 years, with a strong focus on methylfolate. Their Optimized Folate formulas provide 1,700 mcg to 8,500 mcg of 5-MTHF, the metabolically active form of folate, which is crucial for maintaining healthy homocysteine levels and supporting cardiovascular and cognitive health. Notably, up to 50% of people of European descent have a genetic variation that reduces MTHFR enzyme activity, making 5-MTHF a superior choice. Life Extension's products are highly recommended, with 98% of customers endorsing them to family and friends. Their formulations are designed to overcome enzyme inefficiencies, ensuring optimal bioavailability.

NOW Foods

NOW Foods is a renowned brand for producing high-quality methylfolate supplements, offering a metabolically active form of folate that supports essential body functions like cell division, neurotransmitter synthesis, and DNA production. Their Methyl Folate supplement, available in 90-tablet packs, provides 1,000 mcg of (6S)-5-MTHF per serving, which is 425% of the Daily Value. This product, first available since 2016, is formulated with Quatrefolic®, a patented form of methylfolate known for its superior bioavailability. NOW Foods ensures GMP quality assurance and maintains a family-owned tradition since 1968. The supplement is vegetarian, vegan, kosher, and non-GMO, making it a reliable choice for various dietary needs.

Seeking Health

Seeking Health is renowned as one of the best producers of methylfolate supplements, offering high-quality products that support healthy methylation, regulate homocysteine levels, and boost energy production. Their Methyl B12 with L-Methylfolate supplement contains 1,360 mcg DFE of folate in the active form of L-5-methyltetrahydrofolate and 1,000 mcg of vitamin B12, ensuring optimal bioavailability. This formula is designed to bypass MTHFR gene mutations, making it essential for individuals with genetic variations. The supplements are manufactured in cGMP-certified facilities, ensuring they meet the highest quality standards. Seeking Health's products are also free from common allergens and artificial ingredients, making them a reliable choice for those seeking effective methylfolate supplementation.

Designs for Health

Designs for Health is a renowned brand in the field of functional medicine, particularly noted for its high-quality methylfolate products. Their L-5-MTHF supplements, such as those using the patented Quatrefolic(r) derivative, are recognized for their high bioavailability and stability, significantly enhancing blood folate levels more effectively than folic acid. With over 35 years of experience, Designs for Health has established itself as a trusted name among healthcare practitioners, offering over 300 research-backed nutritional products. Their methylfolate formulas are formulated with the natural [6S] isomer, ensuring optimal bioactivity. This commitment to quality and science has made Designs for Health a leader in the dietary supplement industry.

Doctor's Best

Doctor's Best is a highly regarded brand for methylfolate supplements, known for its Fully Active Folate product that contains 400 mcg of the active form of folate, (6S)-5-methyltetrahydrofolic acid (5-MTHF), which can be immediately used by the body. This supplement is gluten-free, non-GMO, and suitable for vegans, making it a versatile option. It also includes 40 mg of vitamin C to stabilize the folate molecule. Doctor's Best Fully Active Folate is third-party tested for ingredient amounts and contaminants, ensuring its quality and purity. This product is recommended for general use, especially for those who require an affordable and reliable source of methylfolate.

Nature's Way

Nature's Way, a leading retail nutrition brand since 1969, is renowned for its high-quality supplements, including methylfolate products. However, specific details about their methylfolate offerings are not provided in the sources. Nature's Way is known for its extensive range of nutritional products, such as the ALIVE multivitamins, and offers various promotions and discounts. The brand emphasizes the use of natural ingredients and has a strong commitment to customer wellness. While they do not specifically highlight methylfolate, their reputation for quality supplements makes them a trusted choice.